Can satellite glial cells be therapeutic targets for pain control?

被引：132
作者：
Jasmin, Luc [1 ,2 ]
Vit, Jean-Philippe [3 ]
Bhargava, Aditi [4 ]
Ohara, Peter T. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA
[2] Cedars Sinai Med Ctr, Dept Neurosurg, Los Angeles, CA 90048 USA
[3] Cedars Sinai Med Ctr, Dept Psychiat, Los Angeles, CA 90048 USA
[4] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA
来源：
NEURON GLIA BIOLOGY | 2010年 / 6卷 / 01期
关键词：
Nociception; trigeminal; immune cells; GABA; RNAi; DORSAL-ROOT GANGLIA; RAT TRIGEMINAL GANGLION; MURINE SENSORY GANGLIA; CHRONIC CONSTRICTION INJURY; SPINAL-CORD; GLUTAMATE TRANSPORTERS; RNA INTERFERENCE; NEUROPATHIC PAIN; DOWN-REGULATION; GENE-TRANSFER;
D O I：
10.1017/S1740925X10000098
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Satellite glial cells (SGCs) undergo phenotypic changes and divide the following injury into a peripheral nerve. Nerve injury, also elicits an immune response and several antigen-presenting cells are found in close proximity to SGCs. Silencing SCG-specific molecules involved in intercellular transport (Connexin 43) or glutamate recycling (glutamine synthase) can dramatically alter nociceptive responses of normal and nerve-injured rats. Transducing SGCs with glutamic acid decarboxylase can produce analgesia in models of trigeminal pain. Taken together these data suggest that SGCs may play a role in the genesis or maintenance of pain and open a range of new possibilities for curing neuropathic pain.
引用
收藏
页码：63 / 71
页数：9
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