Can satellite glial cells be therapeutic targets for pain control?

被引：132
作者：
Jasmin, Luc [1 ,2 ]
Vit, Jean-Philippe [3 ]
Bhargava, Aditi [4 ]
Ohara, Peter T. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA
[2] Cedars Sinai Med Ctr, Dept Neurosurg, Los Angeles, CA 90048 USA
[3] Cedars Sinai Med Ctr, Dept Psychiat, Los Angeles, CA 90048 USA
[4] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA
来源：
NEURON GLIA BIOLOGY | 2010年 / 6卷 / 01期
关键词：
Nociception; trigeminal; immune cells; GABA; RNAi; DORSAL-ROOT GANGLIA; RAT TRIGEMINAL GANGLION; MURINE SENSORY GANGLIA; CHRONIC CONSTRICTION INJURY; SPINAL-CORD; GLUTAMATE TRANSPORTERS; RNA INTERFERENCE; NEUROPATHIC PAIN; DOWN-REGULATION; GENE-TRANSFER;
D O I：
10.1017/S1740925X10000098
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Satellite glial cells (SGCs) undergo phenotypic changes and divide the following injury into a peripheral nerve. Nerve injury, also elicits an immune response and several antigen-presenting cells are found in close proximity to SGCs. Silencing SCG-specific molecules involved in intercellular transport (Connexin 43) or glutamate recycling (glutamine synthase) can dramatically alter nociceptive responses of normal and nerve-injured rats. Transducing SGCs with glutamic acid decarboxylase can produce analgesia in models of trigeminal pain. Taken together these data suggest that SGCs may play a role in the genesis or maintenance of pain and open a range of new possibilities for curing neuropathic pain.
引用
收藏
页码：63 / 71
页数：9
相关论文
共 50 条
  • [21] Satellite Glial Cells: No Longer the Most Overlooked Glia
    Birren, Susan J.
    Goodrich, Lisa V.
    Segal, Rosalind A.
    COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2025, 17 (01):
  • [22] Differential activation of spinal and parabrachial glial cells in a neuropathic pain model
    Mussetto, Valeria
    Moen, Aurora
    Trofimova, Lidia
    Sandkuehler, Juergen
    Hogri, Roni
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2023, 17
  • [23] Single-cell analysis of dorsal root ganglia reveals metalloproteinase signaling in satellite glial cells and pain
    Tonello, Raquel
    Prudente, Arthur Silveira
    Lee, Sang Hoon
    Cohen, Cinder Faith
    Xie, Wenrui
    Paranjpe, Aditi
    Roh, Jueun
    Park, Chul-Kyu
    Chung, Gehoon
    Strong, Judith A.
    Zhang, Jun-Ming
    Berta, Temugin
    BRAIN BEHAVIOR AND IMMUNITY, 2023, 113 : 401 - 414
  • [24] Expression and contribution of satellite glial cells purinoceptors to pain transmission in sensory ganglia: an update
    Villa, Giovanni
    Fumagalli, Marta
    Verderio, Claudia
    Abbracchio, Maria P.
    Ceruti, Stefania
    NEURON GLIA BIOLOGY, 2010, 6 (01) : 31 - 42
  • [25] The Role of Satellite Glial Cells, Astrocytes, and Microglia in Oxaliplatin-Induced Neuropathic Pain
    Lee, Ji Hwan
    Kim, Woojin
    BIOMEDICINES, 2020, 8 (09)
  • [26] Spinal cord injury induced neuropathic pain: Molecular targets and therapeutic approaches
    Schomberg, Dominic
    Miranpuri, Gurwattan
    Duellman, Tyler
    Crowell, Andrew
    Vemuganti, Raghu
    Resnick, Daniel
    METABOLIC BRAIN DISEASE, 2015, 30 (03) : 645 - 658
  • [27] Glial cells in orofacial pain
    Vazquez Mendez, Araceli
    Ita Amador, Martha Lucia
    ENEUROBIOLOGIA, 2022, 13 (32):
  • [28] Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation
    Liu, Feng-Yu
    Sun, Yan-Ni
    Wang, Fa-Tian
    Li, Qian
    Su, Li
    Zhao, Zi-Fang
    Meng, Xiang-Ling
    Zhao, Hong
    Wu, Xi
    Sun, Qian
    Xing, Guo-Gang
    Wan, You
    BRAIN RESEARCH, 2012, 1427 : 65 - 77
  • [29] Opioid Receptors in Immune and Glial Cells-Implications for Pain Control
    Machelska, Halina
    Celik, Melih Oe
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [30] Satellite glial cells promote regenerative growth in sensory neurons
    Avraham, Oshri
    Deng, Pan-Yue
    Jones, Sara
    Kuruvilla, Rejji
    Semenkovich, Clay F.
    Klyachko, Vitaly A.
    Cavalli, Valeria
    NATURE COMMUNICATIONS, 2020, 11 (01)
12345