Sirtuins at a glance

被引:239
作者
Nakagawa, Takashi [1 ]
Guarente, Leonard [1 ]
机构
[1] MIT, Dept Biol, Paul F Glenn Lab Sci Aging, Cambridge, MA 02139 USA
关键词
ACETYL-COA SYNTHETASE; FATTY-ACID OXIDATION; GENE-EXPRESSION; MAMMALIAN SIR2; GLUCOSE-HOMEOSTASIS; HISTONE DEACETYLASE; INSULIN-SECRETION; METABOLIC DISEASE; INCREASED DOSAGE; CELL-SURVIVAL;
D O I
10.1242/jcs.081067
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
[No abstract available]
引用
收藏
页码:833 / 838
页数:6
相关论文
共 90 条
[51]   Mammalian SIRT1 represses forkhead transcription factors [J].
Motta, MC ;
Divecha, N ;
Lemieux, M ;
Kamel, C ;
Chen, D ;
Gu, W ;
Bultsma, Y ;
McBurney, M ;
Guarente, L .
CELL, 2004, 116 (04) :551-563
[52]   Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice [J].
Moynihan, KA ;
Grimm, AA ;
Plueger, MM ;
Bernal-Mizrachi, E ;
Ford, E ;
Cras-Méneur, C ;
Permutt, MA ;
Imai, SI .
CELL METABOLISM, 2005, 2 (02) :105-117
[53]   SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle [J].
Nakagawa, Takashi ;
Lomb, David J. ;
Haigis, Marcia C. ;
Guarente, Leonard .
CELL, 2009, 137 (03) :560-570
[54]   Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1 [J].
Nakahata, Yasukazu ;
Sahar, Saurabh ;
Astarita, Giuseppe ;
Kaluzova, Milota ;
Sassone-Corsi, Paolo .
SCIENCE, 2009, 324 (5927) :654-657
[55]   SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells [J].
Nasrin, Nargis ;
Wu, Xiaoping ;
Fortier, Eric ;
Feng, Yajun ;
Bare, Olivia Claire ;
Chen, Sumiao ;
Ren, Xianglin ;
Wu, Zhidan ;
Streeper, Ryan S. ;
Bordone, Laura .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (42) :31995-32002
[56]   The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase [J].
North, BJ ;
Marshall, BL ;
Borra, MT ;
Denu, JM ;
Verdin, E .
MOLECULAR CELL, 2003, 11 (02) :437-444
[57]   SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging [J].
Oberdoerffer, Philipp ;
Michan, Shaday ;
Mcvay, Michael ;
Mostoslavsky, Raul ;
Vann, James ;
Park, Sang-Kyu ;
Hartlerode, Andrea ;
Stegmuller, Judith ;
Hafner, Angela ;
Loerch, Patrick ;
Wright, Sarah M. ;
Mills, Kevin D. ;
Bonni, Azad ;
Yankner, Bruce A. ;
Scully, Ralph ;
Prolla, Tomas A. ;
Alt, Frederick W. ;
Sinclair, David A. .
CELL, 2008, 135 (05) :907-918
[58]   Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1 [J].
Ogura, Masahito ;
Nakamura, Yasuhiko ;
Tanaka, Daisuke ;
Zhuang, Xiaotong ;
Fujita, Yoshihito ;
Obara, Akio ;
Hamasaki, Akihiro ;
Hosokawa, Masaya ;
Inagaki, Nobuya .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 393 (01) :73-78
[59]   The possible implication of trans-resveratrol in the cardioprotective effects of long-term moderate wine consumption [J].
Orallo, F ;
Alvarez, E ;
Camiña, M ;
Leiro, JM ;
Gómez, E ;
Fernández, P .
MOLECULAR PHARMACOLOGY, 2002, 61 (02) :294-302
[60]   Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease [J].
Outeiro, Tiago Fleming ;
Kontopoulos, Eirene ;
Altmann, Stephen M. ;
Kufareva, Irina ;
Strathearn, Katherine E. ;
Amore, Allison M. ;
Volk, Catherine B. ;
Maxwell, Michele M. ;
Rochet, Jean-Christophe ;
McLean, Pamela J. ;
Young, Anne B. ;
Abagyan, Ruben ;
Feany, Mel B. ;
Hyman, Bradley T. ;
Kazantsev, Aleksey G. .
SCIENCE, 2007, 317 (5837) :516-519