Sirtuins at a glance

被引:239
作者
Nakagawa, Takashi [1 ]
Guarente, Leonard [1 ]
机构
[1] MIT, Dept Biol, Paul F Glenn Lab Sci Aging, Cambridge, MA 02139 USA
关键词
ACETYL-COA SYNTHETASE; FATTY-ACID OXIDATION; GENE-EXPRESSION; MAMMALIAN SIR2; GLUCOSE-HOMEOSTASIS; HISTONE DEACETYLASE; INSULIN-SECRETION; METABOLIC DISEASE; INCREASED DOSAGE; CELL-SURVIVAL;
D O I
10.1242/jcs.081067
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
[No abstract available]
引用
收藏
页码:833 / 838
页数:6
相关论文
共 90 条
[1]   A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis [J].
Ahn, Bong-Hyun ;
Kim, Hyun-Seok ;
Song, Shiwei ;
Lee, In Hye ;
Liu, Jie ;
Vassilopoulos, Athanassios ;
Deng, Chu-Xia ;
Finkel, Toren .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (38) :14447-14452
[2]   SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγ Activity through Deacetylation of Specific Lysine Residues in Mammals [J].
Akieda-Asai, Sayaka ;
Zaima, Nobuhiro ;
Ikegami, Koji ;
Kahyo, Tomoaki ;
Yao, Ikuko ;
Hatanaka, Takahiro ;
Iemura, Shun-ichiro ;
Sugiyama, Rika ;
Yokozeki, Takeaki ;
Eishi, Yoshinobu ;
Koike, Morio ;
Ikeda, Kyoji ;
Chiba, Takuya ;
Yamaza, Haruyoshi ;
Shimokawa, Isao ;
Song, Si-Young ;
Matsuno, Akira ;
Mizutani, Akiko ;
Sawabe, Motoji ;
Chao, Moses V. ;
Tanaka, Masashi ;
Kanaho, Yasunori ;
Natsume, Tohru ;
Sugimura, Haruhiko ;
Date, Yukari ;
McBurney, Michael W. ;
Guarente, Leonard ;
Setou, Mitsutoshi .
PLOS ONE, 2010, 5 (07)
[3]   Sirt1 regulates aging and resistance to oxidative stress in the heart [J].
Alcendor, Ralph R. ;
Gao, Shumin ;
Zhai, Peiyong ;
Zablocki, Daniela ;
Holle, Eric ;
Yu, Xianzhong ;
Tian, Bin ;
Wagner, Thomas ;
Vatner, Stephen F. ;
Sadoshima, Junichi .
CIRCULATION RESEARCH, 2007, 100 (10) :1512-1521
[4]   SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice [J].
Banks, Alexander S. ;
Kon, Ning ;
Knight, Colette ;
Matsumoto, Michihiro ;
Gutierrez-Juarez, Roger ;
Rossetti, Luciano ;
Gu, Wei ;
Accili, Domenico .
CELL METABOLISM, 2008, 8 (04) :333-341
[5]   Resveratrol improves health and survival of mice on a high-calorie diet [J].
Baur, Joseph A. ;
Pearson, Kevin J. ;
Price, Nathan L. ;
Jamieson, Hamish A. ;
Lerin, Carles ;
Kalra, Avash ;
Prabhu, Vinayakumar V. ;
Allard, Joanne S. ;
Lopez-Lluch, Guillermo ;
Lewis, Kaitlyn ;
Pistell, Paul J. ;
Poosala, Suresh ;
Becker, Kevin G. ;
Boss, Olivier ;
Gwinn, Dana ;
Wang, Mingyi ;
Ramaswamy, Sharan ;
Fishbein, Kenneth W. ;
Spencer, Richard G. ;
Lakatta, Edward G. ;
Le Couteur, David ;
Shaw, Reuben J. ;
Navas, Placido ;
Puigserver, Pere ;
Ingram, Donald K. ;
de Cabo, Rafael ;
Sinclair, David A. .
NATURE, 2006, 444 (7117) :337-342
[6]   SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol [J].
Boily, G. ;
He, X. H. ;
Pearce, B. ;
Jardine, K. ;
McBurney, M. W. .
ONCOGENE, 2009, 28 (32) :2882-2893
[7]   Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells [J].
Bordone, L ;
Motta, MC ;
Picard, F ;
Robinson, A ;
Jhala, US ;
Apfeld, J ;
McDonagh, T ;
Lemieux, M ;
McBurney, M ;
Szilvasi, A ;
Easlon, EJ ;
Lin, SJ ;
Guarente, L .
PLOS BIOLOGY, 2006, 4 (02) :210-220
[8]   Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [J].
Brunet, A ;
Sweeney, LB ;
Sturgill, JF ;
Chua, KF ;
Greer, PL ;
Lin, YX ;
Tran, H ;
Ross, SE ;
Mostoslavsky, R ;
Cohen, HY ;
Hu, LS ;
Cheng, HL ;
Jedrychowski, MP ;
Gygi, SP ;
Sinclair, DA ;
Alt, FW ;
Greenberg, ME .
SCIENCE, 2004, 303 (5666) :2011-2015
[9]   Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System [J].
Cakir, Isin ;
Perello, Mario ;
Lansari, Omar ;
Messier, Norma J. ;
Vaslet, Charles A. ;
Nillni, Eduardo A. .
PLOS ONE, 2009, 4 (12)
[10]   AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity [J].
Canto, Carles ;
Gerhart-Hines, Zachary ;
Feige, Jerome N. ;
Lagouge, Marie ;
Noriega, Lilia ;
Milne, Jill C. ;
Elliott, Peter J. ;
Puigserver, Pere ;
Auwerx, Johan .
NATURE, 2009, 458 (7241) :1056-U140