MicroRNA - implications for cancer

被引：420
作者：
Sassen, Stefanie [1 ]
Miska, Eric A. [2 ]
Caldas, Carlos [1 ]
机构：
[1] Univ Cambridge, Li Ka Shing Ctr, Canc Res UK Cambrige Res Inst, Dept Oncol Breast Canc Funct Genom Lab, Cambridge CB2 0RE, England
[2] Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Dept Biochem, Cambridge, England
来源：
VIRCHOWS ARCHIV | 2008年 / 452卷 / 01期
关键词：
microRNA; miRNA; cancer; pathogenesis; development;
D O I：
10.1007/s00428-007-0532-2
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression post-transcriptionally. After the discovery of the first miRNA in the roundworm Caenorhabditis elegans, these short regulatory RNAs have been found to be an abundant class of RNAs in plants, animals, and DNA viruses. About 3% of human genes encode for miRNAs, and up to 30% of human protein coding genes may be regulated by miRNAs. MicroRNAs play a key role in diverse biological processes, including development, cell proliferation, differentiation, and apoptosis. Accordingly, altered miRNA expression is likely to contribute to human disease, including cancer. This review will summarize the emerging knowledge of the connections between human miRNA biology and different aspects of carcinogenesis. Various techniques available to investigate miRNAs will also be discussed.
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页码：1 / 10
页数：10
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