DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring

被引：8

作者：

Zambrano, Elena ^{[1
]}

Rodriguez-Gonzalez, Guadalupe L. ^{[1
]}

Reyes-Castro, Luis A. ^{[1
]}

Bautista, Claudia J. ^{[1
]}

Castro-Rodriguez, Diana C. ^{[1
,2
]}

Juarez-Pilares, Gimena ^{[1
]}

Ibanez, Carlos A. ^{[1
]}

Hernandez-Rojas, Alejandra ^{[1
]}

Nathanielsz, Peter W. ^{[3
]}

Montano, Sara ^{[4
]}

Arredondo, Armando ^{[5
]}

Huang, Fengyang ^{[6
]}

Bolanos-Jimenez, Francisco ^{[7
]}

机构：

[1] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City 14080, DF, Mexico

[2] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, CONACyT Catedras, Mexico City 14080, DF, Mexico

[3] Univ Wyoming, Dept Anim Sci, Laramie, WY 82071 USA

[4] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Anim Nutr, Mexico City 14080, DF, Mexico

[5] Inst Nacl Salud Publ, Ctr Hlth Syst Res, Cuernavaca 62100, Morelos, Mexico

[6] Hosp Infantil Mexico Dr Federico Gomez, Lab Pharmacol & Toxicol, Mexico City 06720, DF, Mexico

[7] Nantes Atlantique Univ, INRAE, UMR1280 Physiol Adaptat Nutr, Univ Nantes, F-44096 Nantes, France

来源：

NUTRIENTS | 2021年 / 13卷 / 12期

关键词：

pregnancy; obesity; breastfeeding; behavioral disorders; LCPUFA; interventions; POLYUNSATURATED FATTY-ACIDS; ALPHA-LINOLENIC ACID; DIET-INDUCED OBESITY; BREAST-MILK; DOCOSAHEXAENOIC ACID; PROTEIN RESTRICTION; MATERNAL OBESITY; VISUAL-ACUITY; FEMALE RATS; BRAIN DHA;

D O I：

10.3390/nu13124243

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We investigated if supplementing obese mothers (MO) with docosahexaenoic acid (DHA) improves milk long-chain polyunsaturated fatty acid (LCPUFA) composition and offspring anxiety behavior. From weaning throughout pregnancy and lactation, female Wistar rats ate chow (C) or a high-fat diet (MO). One month before mating and through lactation, half the mothers received 400 mg DHA kg(-1) d(-1) orally (C+DHA or MO+DHA). Offspring ate C after weaning. Maternal weight, total body fat, milk hormones, and milk nutrient composition were determined. Pups' milk nutrient intake was evaluated, and behavioral anxiety tests were conducted. MO exhibited increased weight and total fat, and higher milk corticosterone, leptin, linoleic, and arachidonic acid (AA) concentrations, and less DHA content. MO male and female offspring had higher omega-6/ omega-3 milk consumption ratios. In the elevated plus maze, female but not male MO offspring exhibited more anxiety. MO+DHA mothers exhibited lower weight, total fat, milk leptin, and AA concentrations, and enhanced milk DHA. MO+DHA offspring had a lower omega-6/omega-3 milk intake ratio and reduced anxiety vs. MO. DHA content was greater in C+DHA milk vs. C. Supplementing MO mothers with DHA improves milk composition, especially LCPUFA content and omega-6/omega-3 ratio reducing offspring anxiety in a sex-dependent manner.

引用

页数：20