Highly Potent SARS-CoV-2 Neutralization by Intravenous Immunoglobulins manufactured from Post-COVID-19 and COVID-19-Vaccinated Plasma Donations

被引：27
|
作者：
Karbiener, Michael [1 ]
Farcet, Maria R. [1 ]
Schwaiger, Julia [1 ]
Powers, Nicholas [2 ]
Lenart, James [2 ]
Stewart, Joseph M. [2 ]
Tallman, Hema [2 ]
Kreil, Thomas R. [1 ]
机构：
[1] Baxter Part Takeda, Global Pathogen Safety, Vienna, Austria
[2] Takeda, BioLife Plasma Serv, Social Circle, GA USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2021年 / 224卷 / 10期
关键词：
Primary immunodeficiency; Secondary immunodeficiency; SARS-CoV-2; SARS coronavirus 2 antibody potency; neutralizing antibodies; COVID-19; intravenous immune globulin; immunoglobulin; plasma; prophylaxis; hyper-immune globulin; CoVIg-19;
D O I：
10.1093/infdis/jiab487
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
From September 2020, some immunoglobulin lots from US plasma contained neutralizing antibodies against the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Paralleled by the increasing numbers of post- coronavirus disease 2019 (COVID-19) donors, immunoglobulin lot antibody positivity increased to 93% by January 2021, at a mean titer of approximately 30 IU/mL. The correlation predicted that anti-SARS-CoV-2 potency would reach 345 IU/mL by July 2021. In addition to post-COVID-19 donors, the rapidly increasing number of plasma donors vaccinated against COVID-19 resulted in a mean antibody titer of >600 IU/mL in July 2021 immunoglobulin lots, with SARS-CoV-2 antibody titers for several lots even higher than those of earlier produced hyperimmune globulin products.
引用
收藏
页码：1707 / 1711
页数：5
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