Feasibility of Combination Therapy with Nab-paclitaxel Plus Gemcitabine in Patients with Recurrent Pancreatic Cancer

被引：4

作者：

Kawaida, Hiromichi ^{[1
]}

Kono, Hiroshi ^{[1
]}

Amemiya, Hidetake ^{[1
]}

Saitou, Ryou ^{[1
]}

Yamamoto, Atsushi ^{[1
]}

Hosomura, Naohiro ^{[1
]}

Watanabe, Mitsuaki ^{[1
]}

Kimura, Ayako ^{[1
]}

Furuya, Shinji ^{[1
]}

Shimizu, Hiroki ^{[1
]}

Akaike, Hidenori ^{[1
]}

Kawaguchi, Yoshihiko ^{[1
]}

Sudo, Makoto ^{[1
]}

Itakura, Jun ^{[1
]}

Hayakawa, Hiroshi ^{[2
]}

Shindo, Hiroko ^{[2
]}

Takahashi, Ei ^{[2
]}

Takano, Shinichi ^{[2
]}

Fukasawa, Mitsuharu ^{[2
]}

Ichikawa, Shintaro ^{[3
]}

Fujii, Hideki ^{[1
]}

Ichikawa, Daisuke ^{[1
]}

机构：

[1] Univ Yamanashi, Dept Surg 1, Fac Med, 1110 Shimokato, Chuou, Yamanashi 4093898, Japan

[2] Univ Yamanashi, Fac Med, Dept Internal Med 1, Chuou, Yamanashi, Japan

[3] Univ Yamanashi, Fac Med, Dept Radiol, Chuou, Yamanashi, Japan

来源：

ANTICANCER RESEARCH | 2018年 / 38卷 / 11期

关键词：

Nab-paclitaxel; gemcitabine; pancreatic cancer; pancreatectomy; RANDOMIZED CONTROLLED-TRIAL; CARBOHYDRATE ANTIGEN 19-9; ADJUVANT CHEMOTHERAPY; REMNANT PANCREAS; PARENTERAL-NUTRITION; CLINICAL-TRIALS; SERUM CA-19-9; PHASE I/II; ADENOCARCINOMA; FOLFIRINOX;

D O I：

10.21873/anticanres.13019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Nab-paclitaxel plus gemcitabine (nab-P+Gem) is one of most reliable and effective regimens for borderline or unresectable pancreatic cancer (PC). However, the feasibility and clinical benefits of this regimen have never been evaluated for patients with recurrent PC after pancreatectomy. The aim of this study was to investigate the feasibility of combination therapy with nab-paclitaxel plus gemcitabine (nab-P+Gem) for patients with recurrent PC. Patients and Methods: Twenty-two patients with recurrent PC received an intravenous infusion of nab-P (125 mg/m(2)) and Gem (1,000 mg/m(2)) on days 1, 8, and 15 of a 4-week cycle. The primary end-point of this study was completion of the 4 cycles. The secondary end-points were the safety, efficacy, and disease control rate. Results: The treatment completion rate of the 4 cycles was 90.9%. The objective response rate was 13.6% and the disease control rate was 63.6%. The median progression free survival was 7.2 months. The most common grade 3 or higher hematological toxicity was neutropenia (72.7%). There was no treatment-related death. Furthermore, the chemotherapeutic effects varied with the time of recurrence. Conclusion: Combination nab-P+Gem therapy was well-tolerated and effective in patients with recurrent PC.

引用

页码：6537 / 6542

页数：6

共 40 条

[21] Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid vs Gemcitabine Following Pancreatic Cancer Resection A Randomized Controlled Trial [J].

Neoptolemos, John P. ;

Stocken, Deborah D. ;

Bassi, Claudio ;

Ghaneh, Paula ;

Cunningham, David ;

Goldstein, David ;

Padbury, Robert ;

Moore, Malcolm J. ;

Gallinger, Steven ;

Mariette, Christophe ;

Wente, Moritz N. ;

Izbicki, Jakob R. ;

Friess, Helmut ;

Lerch, Markus M. ;

Dervenis, Christos ;

Olah, Attila ;

Butturini, Giovanni ;

Doi, Ryuichiro ;

Lind, Pehr A. ;

Smith, David ;

Valle, Juan W. ;

Palmer, Daniel H. ;

Buckels, John A. ;

Thompson, Joyce ;

McKay, Colin J. ;

Rawcliffe, Charlotte L. ;

Buechler, Markus W. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 304 (10) :1073-1081

[22] Review article: anorexia and cachexia in gastrointestinal cancer [J].

Ockenga, J ;

Valentini, L .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2005, 22 (07) :583-594

[23] Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer - A Randomized controlled trial [J].

Oettle, Helmut ;

Post, Stefan ;

Neuhaus, Peter ;

Gellert, Klaus ;

Langrehr, Jan ;

Ridwelski, Karsten ;

Schramm, Harald ;

Fahlke, Joerg ;

Zuelke, Carl ;

Burkart, Christof ;

Gutberlet, Klaus ;

Kettner, Erika ;

Schmalenberg, Harald ;

Weigang-Koehler, Karin ;

Bechstein, Wolf-Otto ;

Niedergethmann, Marco ;

Schmidt-Wolf, Ingo ;

Roll, Lars ;

Doerken, Bernd ;

Riess, Hanno .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (03) :267-277

[24] Nab-Paclitaxel and Gemcitabine in Advanced Pancreatic Cancer: The One-year Experience of the National Cancer Institute of Naples [J].

Ottaiano, Alessandro ;

Capozzi, Monica ;

De Divitiis, Chiara ;

Von Arx, Claudia ;

Di Girolamo, Elena ;

Nasti, Guglielmo ;

Cavalcanti, Ernesta ;

Tatangelo, Fabiana ;

Romano, Giovanni ;

Avallone, Antonio ;

Tafuto, Salvatore .

ANTICANCER RESEARCH, 2017, 37 (04) :1975-1978

[25] Neoadjuvant Nab-paclitaxel and Gemcitabine in Borderline Resectable or Locally Advanced Unresectable Pancreatic Adenocarcinoma in Patients Who Are Ineligible for FOLFIRINOX [J].

Peterson, Shawn L. ;

Husnain, Muhammad ;

Pollack, Terri ;

Pimentel, Agustin ;

Loaiza-Bonilla, Arturo ;

Westendorf-Overley, Colleen ;

Ratermann, Kelley ;

Anthony, Lowell ;

Desimone, Philip ;

Goel, Gaurav ;

Kudrimoti, Mahesh ;

Dineen, Sean ;

Tzeng, Ching-Wei D. ;

Hosein, Peter J. .

ANTICANCER RESEARCH, 2018, 38 (07) :4035-4039

[26] FOLFIRINOX-Based Neoadjuvant Therapy in Borderline Resectable or Unresectable Pancreatic Cancer A Meta-Analytical Review of Published Studies [J].

Petrelli, Fausto ;

Coinu, Andrea ;

Borgonovo, Karen ;

Cabiddu, Mary ;

Ghilardi, Mara ;

Lonati, Veronica ;

Aitini, Enrico ;

Barni, Sandro .

PANCREAS, 2015, 44 (04) :515-521

[27]

Richter E, 2012, ANTICANCER RES, V32, P2111

[28] Extended Neoadjuvant Chemotherapy for Borderline Resectable Pancreatic Cancer Demonstrates Promising Postoperative Outcomes and Survival [J].

Rose, J. Bart ;

Rocha, Flavio G. ;

Alseidi, Adnan ;

Biehl, Thomas ;

Moonka, Ravi ;

Ryan, John A. ;

Lin, Bruce ;

Picozzi, Vincent ;

Helton, Scott .

ANNALS OF SURGICAL ONCOLOGY, 2014, 21 (05) :1530-1537

[29] Completion pancreatectomy for recurrent pancreatic cancer in the remnant pancreas: report of six cases and a review of the literature [J].

Shima, Yasuo ;

Okabayashi, Takehiro ;

Kozuki, Akihito ;

Sumiyoshi, Tatsuaki ;

Tokumaru, Teppei ;

Saisaka, Yuichi ;

Date, Keiichi ;

Iwata, Jun .

LANGENBECKS ARCHIVES OF SURGERY, 2015, 400 (08) :973-978

[30] Original Scientific Reports: Clinicopathological Findings of Remnant Pancreatic Cancers in Survivors Following Curative Resections of Pancreatic Cancers [J].

Suzuki, Shuji ;

Furukawa, Toru ;

Oshima, Nana ;

Izumo, Wataru ;

Shimizu, Kyoko ;

Yamamoto, Masakazu .

WORLD JOURNAL OF SURGERY, 2016, 40 (04) :974-981

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