Diversity-oriented synthesis - Towards the optimal screening collection: A synthesis strategy

被引：459
作者：
Nielsen, Thomas E.
Schreiber, Stuart L. [1 ,2 ]
机构：
[1] Harvard Univ, Dept Chem & Chem Biol, Howard Hughes Med Inst, Chem Biol Program,Broad Inst Harvard, Cambridge, MA 02142 USA
[2] MIT, Cambridge, MA 02142 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 01期
关键词：
build/couple/pair; diversity-oriented synthesis; molecular diversity; small molecules; synthesis design;
D O I：
10.1002/anie.200703073
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：48 / 56
页数：9
相关论文
共 53 条
[1]  
[Anonymous], 2003, Angewandte Chemie, DOI [DOI 10.1002/ANGE.200352361, 10.1002/ange.200352361]
[2]   Charting biological and chemical space: PSSC and SCONP as guiding principles for the development of compound collections based on natural product scaffolds [J].
Arve, Lars ;
Voigt, Tobias ;
Waldmann, Herbert .
QSAR & COMBINATORIAL SCIENCE, 2006, 25 (5-6) :449-456
[3]   Exploring new chemical space by stereocontrolled diversity-oriented synthesis [J].
Arya, P ;
Joseph, R ;
Gan, ZH ;
Rakic, B .
CHEMISTRY & BIOLOGY, 2005, 12 (02) :163-180
[4]   Chemical library synthesis using convergent approaches [J].
Beeler, AB ;
Schaus, SE ;
Porco, JA .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2005, 9 (03) :277-284
[5]  
Breinbauer R, 2002, ANGEW CHEM INT EDIT, V41, P2879
[6]  
BREINBAUER R, 2002, ANGEW CHEM, V114, P3002
[7]   Microwave-assisted intramolecular [2+2] allenic cycloaddition reaction for the rapid assembly of bicyclo[4.2.0]octa-1,6-dienes and bicyclo[5.2.0]nona-1,7-dienes [J].
Brummond, KM ;
Chen, DT .
ORGANIC LETTERS, 2005, 7 (16) :3473-3475
[8]   Allenes and transition metals: A diverging approach to heterocycles [J].
Brummond, KM ;
Mitasev, B .
ORGANIC LETTERS, 2004, 6 (13) :2245-2248
[9]  
Burke M. D., 2004, ANGEW CHEM, V116, P48
[10]   Generating diverse skeletons of small molecules combinatorially [J].
Burke, MD ;
Berger, EM ;
Schreiber, SL .
SCIENCE, 2003, 302 (5645) :613-618
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