Dupilumab to Treat Type 2 Inflammatory Diseases in Children and Adolescents

被引：61

作者：

Licari, Amelia ^{[1
]}

Castagnoli, Riccardo ^{[1
]}

Marseglia, Alessia ^{[1
]}

Olivero, Francesca ^{[1
]}

Votto, Martina ^{[1
]}

Ciprandi, Giorgio ^{[2
]}

Marseglia, Gian Luigi ^{[1
]}

机构：

[1] Univ Pavia, Pediat Clin, Dept Pediat, Fdn IRCCS Policlin San Matteo, Viale Golgi 19, I-27100 Pavia, Italy

[2] Allergy Clin, Casa Cura Villa Montallegro, Genoa, Italy

来源：

PEDIATRIC DRUGS | 2020年 / 22卷 / 03期

关键词：

SEVERE ATOPIC-DERMATITIS; IL-4; RECEPTOR; ASTHMA; MECHANISMS; URTICARIA; CYTOKINES; RESPONSES; SUBUNIT; PLACEBO; CELLS;

D O I：

10.1007/s40272-020-00387-2

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

During the past decade, significant therapeutic progress has been made in the field of allergic diseases, mainly concerning the pathogenic role of type 2 inflammation. Biologics targeting specific key cytokines, such as interleukin (IL)-4, IL-5, and IL-13, as well as IgE, have emerged as promising innovative therapies for allergic disorders. In this context, dupilumab has emerged as one of the most successful therapies targeting the IL-4R axis. Dupilumab is a human IgG4 antibody anti-IL-4 receptor (IL-4R) alpha-subunit that blocks IL-4R signaling induced by both IL-4 and IL-13, downregulating the molecular pathways that drive type 2 inflammatory diseases, including atopic dermatitis, allergic rhinitis, allergic asthma, chronic rhinosinusitis with nasal polyps, and eosinophilic esophagitis. This review presents the most recent evidence on dupilumab for the treatment of type 2 inflammatory diseases and discusses the future perspective, focusing on the pediatric age group and adolescents.

引用

页码：295 / 310

页数：16

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