Molecular Epidemiology of Coxiella burnetii from Ruminants in Q Fever Outbreak, the Netherlands

被引：134

作者：

Roest, Hendrik I. J. ^{[1
]}

Ruuls, Robin C. ^{[1
]}

Tilburg, Jeroen J. H. C. ^{[2
]}

Nabuurs-Franssen, Marrigje H. ^{[2
,3
]}

Klaassen, Corne H. W. ^{[2
]}

Vellema, Piet ^{[4
]}

van den Brom, Rene ^{[4
]}

Dercksen, Daan ^{[4
]}

Wouda, Willem ^{[4
]}

Spierenburg, Marcel A. H. ^{[5
]}

van der Spek, Arco N. ^{[5
]}

Buijs, Rob ^{[1
]}

de Boer, Albert G. ^{[1
]}

Willemsen, Peter Th J. ^{[1
]}

van Zijderveld, Fred G. ^{[1
]}

机构：

[1] Wageningen UR, Cent Vet Inst, NL-8219 PH Lelystad, Netherlands

[2] Canisius Wilhelmina Hosp, Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[4] Anim Hlth Serv, Deventer, Netherlands

[5] Food & Consumer Prod Safety Author, The Hague, Netherlands

来源：

EMERGING INFECTIOUS DISEASES | 2011年 / 17卷 / 04期

关键词：

INFECTION; HISTORY; GOATS;

D O I：

10.3201/eid1704.101562

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Q fever is a zoonosis caused by the bacterium Coxiella burnetii. One of the largest reported outbreaks of Q fever in humans occurred in the Netherlands starting in 2007; epidemiologic investigations identified small ruminants as the source. To determine the genetic background of C. burnetii in domestic ruminants responsible for the human Q fever outbreak, we genotyped 126 C. burnetii-positive samples from ruminants by using a 10-loci multilocus variable-number tandem-repeat analyses panel and compared them with internationally known genotypes. One unique genotype predominated in dairy goat herds and 1 sheep herd in the human Q fever outbreak area in the south of the Netherlands. On the basis of 4 loci, this genotype is similar to a human genotype from the Netherlands. This finding strengthens the probability that this genotype of C. burnetii is responsible for the human Q fever epidemic in the Netherlands.

引用

页码：668 / 675

页数：8

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