The double-edged effect of autophagy in pancreatic beta cells and diabetes

被引：93

作者：

Chen, Ze-fang ^{[1
]}

Li, Yan-bo ^{[1
]}

Han, Jun-yong ^{[2
]}

Wang, Jing ^{[1
]}

Yin, Jia-jing ^{[1
]}

Li, Jing-bo ^{[1
]}

Tian, Hui ^{[1
]}

机构：

[1] Harbin Med Coll, Dept Endocrinol, Affiliated Hosp 1, Harbin, Heilongjiang Pr, Peoples R China

[2] Zhongshan Med Univ, Hosp 5, Dept Cardiol, Zhuhai, Guangdong, Peoples R China

来源：

AUTOPHAGY | 2011年 / 7卷 / 01期

关键词：

autophagy; autophagic cell death; pancreatic beta cell; diabetes; insulin; ENDOPLASMIC-RETICULUM STRESS; MEDIATED CLEAVAGE; MAMMALIAN-CELLS; INSULIN; APOPTOSIS; DEATH; BIOSYNTHESIS; DEGRADATION; HOMEOSTASIS; PROINSULIN;

D O I：

10.4161/auto.7.1.13607

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is an intracellular catabolic system, which enables cells to capture cytoplasmic components for degradation within lysosomes. Autophagy is involved in development, differentiation and tissue remodeling in various organisms, and is also implicated in certain diseases. Recent studies demonstrate that autophagy is necessary to maintain architecture and function of pancreatic beta cells. Altered autophagy is also involved in pancreatic beta cell death. Whether autophagy plays a protective or harmful role in diabetes is still not clear. In this review, we will summarize the current knowledge about the role of autophagy in pancreatic beta cell and diabetes.

引用

页码：12 / 16

页数：5

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