Two Novel Aspochalasins from the Gut Fungus Aspergillus sp Z4

被引：13

作者：

Li, Xinyang ^{[1
]}

Ding, Wanjing ^{[1
]}

Wang, Pinmei ^{[1
]}

Xu, Jinzhong ^{[1
]}

机构：

[1] Zhejiang Univ, Inst Marine Biol, Ocean Coll, Zhoushan 316021, Peoples R China

来源：

MARINE DRUGS | 2018年 / 16卷 / 10期

关键词：

aspochalasin; tricyclic fused; gut fungus; cytotoxicity; SPICARIA-ELEGANS; CYTOTOXIC CYTOCHALASANS; GENE-CLUSTER; CHAETOGLOBOSIN; DERIVATIVES; FLAVIPES; CELLS; METABOLITE;

D O I：

10.3390/md16100343

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two novel aspochalasins, tricochalasin A (1) and aspochalasin A2 (2), along with three known compounds (3-5) have been isolated from the different culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. Compound 1 contains a rare 5/6/6 tricyclic ring fused with the aspochalasin skeleton. The structures were determined on the basis of electrospray ionisation mass spectroscopy (ESIMS), nuclear magnetic resonance (NMR) spectral data, and the absolute configurations were further confirmed by modified Mosher's method. Cytotoxicity against the prostate cancer PC3 cell line were assayed by the MTT method. Compound 3 showed strong activity while the remaining compounds showed weak activity.

引用

页数：9

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