Compare risk factors associated with postoperative infectious complication in Crohn's disease with and without preoperative infliximab therapy: a cohort study

被引：14

作者：

Tang, Shasha ^{[1
]}

Dong, Xue ^{[2
]}

Liu, Wei ^{[1
]}

Qi, Weilin ^{[1
]}

Ye, Lingna ^{[3
]}

Yang, Xiaoyan ^{[1
]}

Cao, Qian ^{[3
]}

Ge, Xiaolong ^{[1
]}

Zhou, Wei ^{[1
]}

机构：

[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gen Surg, Hangzhou 310016, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Radiol, Hangzhou 310016, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, Hangzhou 310016, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | 2020年 / 35卷 / 04期

基金：

中国国家自然科学基金; 浙江省自然科学基金;

关键词：

Infliximab; Crohn's disease; Infectious complications; Risk factors; C-REACTIVE PROTEIN; ERYTHROCYTE SEDIMENTATION-RATE; INFLAMMATORY-BOWEL-DISEASE; NECROSIS FACTOR THERAPY; MORBIDITY; AGENTS;

D O I：

10.1007/s00384-019-03481-1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Purposes The incidence of postoperative complication is higher in Crohn's disease (CD) compared with other intestinal disease. There is less published data yet on the comparison of risk factors to predict postoperative complications in CD exposed and unexposed to previous infliximab therapy. Also the relationship between infliximab and postoperative infectious complications is still controversial. Our aim is to compare the risk factors to predict infectious complications in CD with and without preoperative infliximab and to clarify relationship between infliximab and infectious complications. Methods This retrospective study included 390 patients from June 2014 to June 2018. Postoperative complications were compared in patients with and without preoperative infliximab. Univariate and multivariable analyses were performed to identify risk factors. Results Eighty-five patients received infliximab within 8 weeks of surgery. A total of 129 patients had postoperative complications, with 35 receiving infliximab. No significant differences of whole postoperative complications were found in CD with and without infliximab (p = 0.073). However, patients receiving infliximab suffered more infectious complications (p = 0.010). Preoperative infliximab was confirmed to be an independent risk factor in infectious complications (p = 0.042). Multivariate analysis suggested that increased erythrocyte sedimentation rate (ESR) was an independent risk factor for infectious complications in patients receiving preoperative infliximab (p = 0.022), and increased C-reactive protein was an independent risk factor in patients not receiving preoperative infliximab (p = 0.019). Conclusions Preoperative use of infliximab <= 8 weeks was independently associated with infectious complications in CD. Risk factors were different in predicting postoperative complications in CD with and without infliximab, and preoperative ESR and C-reactive protein were risk factors, respectively.

引用

页码：727 / 737

页数：11

共 26 条

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