The Spatial-Temporal Ordering of Amyloid Pathology and Opportunities for PET Imaging

被引：41

作者：

Fantoni, Enrico ^{[1
]}

Collij, Lyduine ^{[2
]}

Alves, Isadora Lopes ^{[2
]}

Buckley, Christopher ^{[1
]}

Farrar, Gill ^{[1
]}

机构：

[1] GE Healthcare, Pharmaceut Diagnost, Chalfont St Giles, Bucks, England

[2] Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Amsterdam UMC, Amsterdam, Netherlands

来源：

JOURNAL OF NUCLEAR MEDICINE | 2020年 / 61卷 / 02期

基金：

欧盟地平线“2020”;

关键词：

amyloid PET; staging; spatial-temporal ordering; pathology; POSITRON-EMISSION-TOMOGRAPHY; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; BETA-DEPOSITION; BRAIN; PLAQUES; RECOMMENDATIONS; ASSOCIATION; DEFINITION; VALIDATION;

D O I：

10.2967/jnumed.119.235879

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Although clinical routine focuses on dichotomous and visual interpretation of amyloid PET, regional image assessment in research settings may yield additional opportunities. Understanding the regional-temporal evolution of amyloid pathology may enable earlier identification of subjects in the Alzheimer Disease pathologic continuum, as well as a finer-grained assessment of pathology beyond traditional dichotomous measures. This review summarizes current research in the detection of regional amyloid deposition patterns and its potential for staging amyloid pathology. Pathology studies, cross-sectional and longitudinal PET-only studies, and comparative PET and autopsy studies are included. Despite certain differences, cortical deposition generally precedes striatal pathology, and in PET-only studies, medial cortical regions are seen to accumulate amyloid earlier than lateral regions. Based on regional amyloid PET, multiple studies have developed and implemented models for staging amyloid pathology that could improve subject selection into secondary prevention trials and visual assessment in clinical routine.

引用

页码：166 / 171

页数：6

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