Improving Epinephrine Responses in Hypoglycemia Unawareness With Real-Time Continuous Glucose Monitoring in Adolescents With Type 1 Diabetes

被引：48

作者：

Ly, Trang T. ^{[1
]}

Hewitt, Jacqueline ^{[1
]}

Davey, Raymond J. ^{[2
]}

Lim, Ee Mun ^{[3
,4
]}

Davis, Elizabeth A. ^{[1
,5
]}

Jones, Timothy W. ^{[1
,5
]}

机构：

[1] Princess Margaret Hosp Children, Dept Endocrinol & Diabet, Perth, WA, Australia

[2] Univ Western Australia, Sch Sport Sci Exercise & Hlth, Perth, WA 6009, Australia

[3] Queen Elizabeth II Med Ctr, PathW Lab Med, Nedlands, WA, Australia

[4] Sir Charles Gairdner Hosp, Dept Endocrinol & Diabet, Nedlands, WA 6009, Australia

[5] Univ Western Australia, Telethon Inst Child Hlth Res, Ctr Child Hlth Res, Perth, WA 6009, Australia

来源：

DIABETES CARE | 2011年 / 34卷 / 01期

关键词：

SUBSEQUENT HYPOGLYCEMIA; AUTONOMIC FAILURE; AWARENESS; IDDM; NEUROENDOCRINE; SYMPTOMS;

D O I：

10.2337/dc10-1042

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE- To determine whether real-time continuous glucose monitoring (CGM) with preset alarms at specific glucose levels would prove a useful tool to achieve avoidance of hypoglycemia and improve the counterregulatory response to hypoglycemia in adolescents with type 1 diabetes with hypoglycemia unawareness. RESEARCH DESIGN AND METHODS- Adolescents with type 1 diabetes with hypoglycemia unawareness underwent hyperinsulinemic hypoglycemic clamp studies at baseline to determine their counterregulatory hormone responses to hypoglycemia. Subjects were then randomized to either standard therapy or real-time CGM for 4 weeks. The clamp study was then repeated. RESULTS- The epinephrine response during hypoglycemia after the intervention was greater in the CGM group than in the standard therapy group. CONCLUSIONS- A greater epinephrine response during hypoglycemia suggests that real-time CGM is a useful clinical tool to improve hypoglycemia unawareness in adolescents with type 1 diabetes.

引用

页码：50 / 52

页数：3

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