Physicochemical characterization of protein-loaded pectin-chitosan nanoparticles prepared by polyelectrolyte complexation

被引：10

作者：

Grabnar, P. Ahlin ^{[1
]}

Kristl, J. ^{[1
]}

机构：

[1] Univ Ljubljana, Fac Pharm, Ljubljana 1000, Slovenia

来源：

PHARMAZIE | 2010年 / 65卷 / 11期

关键词：

D O I：

10.1691/ph.2010.0197

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Recent advances in nanotechnology applied to proteins are directed towards safer and simpler methods of preparation, using naturally occurring polymers such as alginate, pectin and chitosan. In this study, pectin-chitosan nanoparticles (NPs) were designed by the mild process of polyelectrolyte complexation, which occurs at room temperature without using sonication or organic solvents. NPs with a mean diameter between 300 and 400 nm and 45 to 86% protein association efficiency were obtained by varying the pectin:chitosan mass ratio and initial protein concentration. A prolonged release profile without burst effect of investigated ovalbumin from pectin-chitosan NPs was determined.

引用

页码：851 / 852

页数：2

共 5 条

[1] Pectin-based systems for colon-specific drug delivery via oral route [J].