The winding road for carbon nanotubes in nanomedicine

被引：106
作者：
Marchesan, Silvia [1 ]
Kostarelos, Kostas [2 ]
Bianco, Alberto [3 ]
Prato, Maurizio [1 ]
机构：
[1] Univ Trieste, Dipartimento Sci Chim & Farmaceut, I-34127 Trieste, Italy
[2] Univ Manchester, Fac Med & Human Sci, Nanomed Lab, Manchester M13 9PT, Lancs, England
[3] CNRS, Inst Biol Mol & Cellulaire, Lab Immunopathol & Chim Therapeut, F-67000 Strasbourg, France
来源：
MATERIALS TODAY | 2015年 / 18卷 / 01期
关键词：
ASBESTOS-LIKE PATHOGENICITY; COMPLEMENT ACTIVATION; PROTEIN CORONA; SURFACE; FUNCTIONALIZATION; NANOMATERIALS; CELLS; BIODEGRADATION; RECOGNITION; ADSORPTION;
D O I：
10.1016/j.mattod.2014.07.009
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Carbon nanotubes (CNTs) are recognized as promising nanomaterials for technological advancement. However, the stigma of structural similarity with asbestos fibers has slowed down progress of CNTs in nanomedicine. Nevertheless, it also prompted thorough studies that have revealed that functionalized CNTs (fCNTs) can biologically behave in a very different and safer manner. Here we review pristine and fCNT fate in biological settings, focusing on the importance of protein interaction, formation of the protein corona, and modulation of immune response. The emerging consensus on the desirable fCNT properties to achieve immunological neutrality, and even biodegradation, shows great promise for CNT adoption in medicine.
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页数：8
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