Synthesis and biological activities of novel 1,3,4-thiadiazole-containing pyrazole oxime derivatives

被引：59
作者：
Dai, Hong [1 ]
Li, Gang [1 ]
Chen, Jia [1 ]
Shi, Yujun [1 ]
Ge, Shushan [1 ]
Fan, Chongguang [1 ]
He, Haibing [1 ]
机构：
[1] Nantong Univ, Coll Chem & Chem Engn, Nantong 226019, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 15期
基金：
中国国家自然科学基金;
关键词：
1,3,4-Thiadiazole; Pyrazole oxime; Synthesis; Bioactivity; INSECTICIDAL ACTIVITIES; FENPYROXIMATE; DESIGN; MOIETY; BIOACTIVITIES; INHIBITORS; ACARICIDE; DISCOVERY; ETHER;
D O I：
10.1016/j.bmcl.2016.04.094
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new library of 1,3,4-thiadiazole-containing pyrazole oximes was designed and synthesized. Their acaricidal and insecticidal activities were evaluated. Bioassay results indicated that some target compounds exhibited good acaricidal and insecticidal properties. Especially, compound 8m had 80% acaricidal activity against Tetranychus cinnabarinus at the concentration of 50 mu g/mL, compound 8f displayed 100% insecticidal activities against Aphis craccivora at the concentration of 50 mu g/mL, compounds 8r and 8w showed 100% insecticidal activities against Plutella xylostella at the concentration of 50 mu g/mL. Furthermore, compounds 8r (LC50 = 19.61 mu g/mL) and 8w (LC50 = 9.78 mu g/mL) possessed comparable or even better insecticidal activities than the control Pyridalyl (LC50 = 17.40 mu g/mL) against P. xylostella. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3818 / 3821
页数：4
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