Secreted Frizzled-Related Protein 2 (sFRP2) Functions as a Melanogenic Stimulator; the Role of sFRP2 in UV-Induced Hyperpigmentary Disorders

被引：53

作者：

Kim, Misun ^{[1
,2
,3
]}

Han, Jae Ho ^{[4
]}

Kim, Jang-Hee ^{[4
]}

Park, Tae Jun ^{[2
,3
,5
]}

Kang, Hee Young ^{[1
,2
,3
]}

机构：

[1] Ajou Univ, Sch Med, Dept Dermatol, Suwon 441749, South Korea

[2] Ajou Univ, Sch Med, Chron Inflammatory Dis Res Ctr, Suwon 441749, South Korea

[3] Ajou Univ, Sch Med, Dept Biomed Sci, Suwon 441749, South Korea

[4] Ajou Univ, Sch Med, Dept Pathol, Suwon 441749, South Korea

[5] Ajou Univ, Sch Med, Dept Biochem, Suwon 441749, South Korea

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2016年 / 136卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

NORMAL HUMAN MELANOCYTES; WNT SIGNALING PATHWAY; WNT/BETA-CATENIN; TRANSCRIPTION FACTOR; PROMOTES MELANOGENESIS; CELL-DIFFERENTIATION; SOLAR LENTIGO; BETA-CATENIN; EXPRESSION; PROLIFERATION;

D O I：

10.1038/JID.2015.365

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In this study, we found that secreted frizzled-related protein 2 (sFRP2) is overexpressed in the hyperpigmentary skin of melasma and solar lentigo and in acutely UV-irradiated skin. To investigate the effect of sFRP2 on melanogenesis, normal human melanocytes were infected with sFRP2-lentivirus or sh-sFRP2. It was found that sFRP2 stimulates melanogenesis through microphthalmia-associated transcription factor and/or tyrosinase upregulation via beta-catenin signaling. The stimulatory action of sFRP2 in pigmentation was further confirmed in melanocytes cocultured with fibroblasts and in ex vivo cultured skin. The findings suggest that sFRP2 functions as a melanogenic stimulator and that it plays a role in the development of UV-induced hyperpigmentary disorders.

引用

页码：236 / 244

页数：9

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