Secreted Frizzled-Related Protein 2 (sFRP2) Functions as a Melanogenic Stimulator; the Role of sFRP2 in UV-Induced Hyperpigmentary Disorders

被引:52
作者
Kim, Misun [1 ,2 ,3 ]
Han, Jae Ho [4 ]
Kim, Jang-Hee [4 ]
Park, Tae Jun [2 ,3 ,5 ]
Kang, Hee Young [1 ,2 ,3 ]
机构
[1] Ajou Univ, Sch Med, Dept Dermatol, Suwon 441749, South Korea
[2] Ajou Univ, Sch Med, Chron Inflammatory Dis Res Ctr, Suwon 441749, South Korea
[3] Ajou Univ, Sch Med, Dept Biomed Sci, Suwon 441749, South Korea
[4] Ajou Univ, Sch Med, Dept Pathol, Suwon 441749, South Korea
[5] Ajou Univ, Sch Med, Dept Biochem, Suwon 441749, South Korea
基金
新加坡国家研究基金会;
关键词
NORMAL HUMAN MELANOCYTES; WNT SIGNALING PATHWAY; WNT/BETA-CATENIN; TRANSCRIPTION FACTOR; PROMOTES MELANOGENESIS; CELL-DIFFERENTIATION; SOLAR LENTIGO; BETA-CATENIN; EXPRESSION; PROLIFERATION;
D O I
10.1038/JID.2015.365
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
In this study, we found that secreted frizzled-related protein 2 (sFRP2) is overexpressed in the hyperpigmentary skin of melasma and solar lentigo and in acutely UV-irradiated skin. To investigate the effect of sFRP2 on melanogenesis, normal human melanocytes were infected with sFRP2-lentivirus or sh-sFRP2. It was found that sFRP2 stimulates melanogenesis through microphthalmia-associated transcription factor and/or tyrosinase upregulation via beta-catenin signaling. The stimulatory action of sFRP2 in pigmentation was further confirmed in melanocytes cocultured with fibroblasts and in ex vivo cultured skin. The findings suggest that sFRP2 functions as a melanogenic stimulator and that it plays a role in the development of UV-induced hyperpigmentary disorders.
引用
收藏
页码:236 / 244
页数:9
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