Secreted Frizzled-Related Protein 2 (sFRP2) Functions as a Melanogenic Stimulator; the Role of sFRP2 in UV-Induced Hyperpigmentary Disorders

被引：52

作者：

Kim, Misun ^{[1
,2
,3
]}

Han, Jae Ho ^{[4
]}

Kim, Jang-Hee ^{[4
]}

Park, Tae Jun ^{[2
,3
,5
]}

Kang, Hee Young ^{[1
,2
,3
]}

机构：

[1] Ajou Univ, Sch Med, Dept Dermatol, Suwon 441749, South Korea

[2] Ajou Univ, Sch Med, Chron Inflammatory Dis Res Ctr, Suwon 441749, South Korea

[3] Ajou Univ, Sch Med, Dept Biomed Sci, Suwon 441749, South Korea

[4] Ajou Univ, Sch Med, Dept Pathol, Suwon 441749, South Korea

[5] Ajou Univ, Sch Med, Dept Biochem, Suwon 441749, South Korea

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2016年 / 136卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

NORMAL HUMAN MELANOCYTES; WNT SIGNALING PATHWAY; WNT/BETA-CATENIN; TRANSCRIPTION FACTOR; PROMOTES MELANOGENESIS; CELL-DIFFERENTIATION; SOLAR LENTIGO; BETA-CATENIN; EXPRESSION; PROLIFERATION;

D O I：

10.1038/JID.2015.365

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In this study, we found that secreted frizzled-related protein 2 (sFRP2) is overexpressed in the hyperpigmentary skin of melasma and solar lentigo and in acutely UV-irradiated skin. To investigate the effect of sFRP2 on melanogenesis, normal human melanocytes were infected with sFRP2-lentivirus or sh-sFRP2. It was found that sFRP2 stimulates melanogenesis through microphthalmia-associated transcription factor and/or tyrosinase upregulation via beta-catenin signaling. The stimulatory action of sFRP2 in pigmentation was further confirmed in melanocytes cocultured with fibroblasts and in ex vivo cultured skin. The findings suggest that sFRP2 functions as a melanogenic stimulator and that it plays a role in the development of UV-induced hyperpigmentary disorders.

引用

页码：236 / 244

页数：9

共 39 条

[1] Stepping up melanocytes to the challenge of UV exposure [J].

Abdel-Malek, Zalfa A. ;

Kadekaro, Ana Luisa ;

Swope, Viki B. .

PIGMENT CELL & MELANOMA RESEARCH, 2010, 23 (02) :171-186

[2] Wnt/β-catenin signaling is stimulated by α-melanocyte-stimulating hormone in melanoma and melanocyte cells: implication in cell differentiation [J].

Bellei, Barbara ;

Pitisci, Angela ;

Catricala, Caterina ;

Larue, Lionel ;

Picardo, Mauro .

PIGMENT CELL & MELANOMA RESEARCH, 2011, 24 (02) :309-325

[3] SFRP2 and Slug Contribute to Cellular Resistance to Apoptosis in Hypertrophic Scars [J].

Chen, Liang ;

Wang, Zhenxiang ;

Li, Shirong ;

Zhao, Guangjian ;

Tian, Maosheng ;

Sun, Zhicheng .

PLOS ONE, 2012, 7 (12)

[4] Pleiotrophin inhibits melanogenesis via Erk1/2-MITF signaling in normal human melanocytes [J].

Choi, Woo Jong ;

Kim, Misun ;

Park, Ji-Youn ;

Park, Tae Jun ;

Kang, Hee Young .

PIGMENT CELL & MELANOMA RESEARCH, 2015, 28 (01) :51-60

[5] Secreted and Transmembrane Wnt Inhibitors and Activators [J].

Cruciat, Cristina-Maria ;

Niehrs, Christof .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2013, 5 (03)

[6] Secreted frizzled-related proteins are required for Wnt/β-catenin signalling activation in the vertebrate optic cup [J].

Esteve, Pilar ;

Sandonis, Africa ;

Ibanez, Carmen ;

Shimono, Akihiko ;

Guerrero, Isabel ;

Bovolenta, Paola .

DEVELOPMENT, 2011, 138 (19) :4179-4184

[7] A Novel Monoclonal Antibody to Secreted Frizzled-Related Protein 2 Inhibits Tumor Growth [J].

Fontenot, Emily ;

Rossi, Emma ;

Mumper, Russell ;

Snyder, Stephanie ;

Siamakpour-Reihani, Sharareh ;

Ma, Ping ;

Hilliard, Eleanor ;

Bone, Bradley ;

Ketelsen, David ;

Santos, Charlene ;

Patterson, Cam ;

Klauber-DeMore, Nancy .

MOLECULAR CANCER THERAPEUTICS, 2013, 12 (05) :685-695

[8] Morphological changes associated with aging - Age spots and the microinflammatory model of skin aging [J].

Goyarts, Earl ;

Muizzuddin, Neelam ;

Maes, Daniel ;

Giacomoni, Paolo U. .

MOLECULAR MECHANISMS AND MODELS OF AGING, 2007, 1119 :32-39

[9] Wnt3a inhibits proliferation but promotes melanogenesis of melan-a cells [J].

Guo, Haiying ;

Yang, Ke ;

Deng, Fang ;

Xing, Yizhan ;

Li, Yuhong ;

Lian, Xiaohua ;

Yang, Tian .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2012, 30 (03) :636-642

[10] Identification of c-MYC as a target of the APC pathway [J].

He, TC ;

Sparks, AB ;

Rago, C ;

Hermeking, H ;

Zawel, L ;

da Costa, LT ;

Morin, PJ ;

Vogelstein, B ;

Kinzler, KW .

SCIENCE, 1998, 281 (5382) :1509-1512

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