Recalling P446. P4501A1 (CYP1A1) opting for clinical application

This review goes back to spectral studies [see Hildebrandt et al., 1968]. The findings of apparent absolute spectra of two interconvertible forms of microsomal mixed function oxidoses are looked back on to recall whether their impact sustained scrutiny or are rather remembered as of sentimental value only. The second part summarizes studies oil the clinical relevance of CYPIA1 with special reference to our investigations. The impact of genetic variability of CYPIA1 oil cancer susceptibility, differential effects of polyphenols and hyperforin oil toxification and detoxification pathways of benzo[a]pyrene, and differential metabolite patterns of 17 beta-estradiol, estrone, and eicosapentaenoic acid are presented.