Diffuse large B-cell lymphoma: a consensus practice statement from the Australasian Lymphoma Alliance

被引：7

作者：

Wight, Joel ^{[1
,2
,3
,4
]}

Hamad, Nada ^{[12
,13
,14
]}

Campbell, Belinda A. ^{[5
,7
,9
]}

Ku, Matthew ^{[8
]}

Lee, Kenneth ^{[15
,16
]}

Rose, Hannah ^{[10
,11
]}

Armytage, Tasman ^{[18
]}

Latimer, Maya ^{[19
,20
]}

Lee, Hui-Peng ^{[21
]}

Lee, Sze-Ting ^{[3
]}

Dickinson, Michael ^{[4
,6
,9
]}

Khor, Richard ^{[3
]}

Verner, Emma ^{[15
,17
]}

机构：

[1] James Cook Univ, Dept Haematol & Bone Marrow Transplantat, Townsville Univ Hosp, Townsville, Qld, Australia

[2] James Cook Univ, Sch Med, Townsville, Qld, Australia

[3] Univ Melbourne, Dept Haematol, Austin Hlth, Melbourne, Vic, Australia

[4] Univ Melbourne, Sch Med, Melbourne, Vic, Australia

[5] Univ Melbourne, Sch Med, Dept Radiat Oncol, Melbourne, Vic, Australia

[6] Univ Melbourne, Peter MacCallum Canc Ctr, Haematol, Melbourne, Vic, Australia

[7] Univ Melbourne, Dept Clin Pathol, Melbourne, Vic, Australia

[8] St Vincents Hosp, Dept Haematol, Melbourne, Vic, Australia

[9] Univ Melbourne, Dept Oncol, Parkville, Vic, Australia

[10] Deakin Univ, Dept Haematol, Univ Hosp, Geelong, Vic, Australia

[11] Deakin Univ, Sch Med, Geelong, Vic, Australia

[12] Univ Notre Dame, Dept Haematol, St Vincents Hosp, Notre Dame, IN USA

[13] Univ Notre Dame, Sch Med, Notre Dame, IN 46556 USA

[14] Univ New South Wales, St Vincents Clin Sch, Kensington, NSW, Australia

[15] Univ Sydney, Sch Med, Sydney, NSW, Australia

[16] Concord Repatriat Gen Hosp, NSW Hlth Pathol, Anat Pathol Dept, Sydney, NSW, Australia

[17] Concord Repatriat Gen Hosp, Dept Haematol, Sydney, NSW, Australia

[18] Gosford Hosp, Dept Haematol, Gosford, NSW, Australia

[19] Australian Natl Univ, Canberra Hosp, Dept Haematol, Canberra, ACT, Australia

[20] Australian Natl Univ, Dept Haematol, Canberra, ACT, Australia

[21] Flinders Med Ctr, Dept Haematol, Adelaide, SA, Australia

来源：

INTERNAL MEDICINE JOURNAL | 2022年 / 52卷 / 09期

关键词：

diffuse large B-cell lymphoma; diagnosis; prognosis; management; POSITRON-EMISSION-TOMOGRAPHY; NON-HODGKIN-LYMPHOMA; RITUXIMAB PLUS CYCLOPHOSPHAMIDE; INTERNATIONAL PROGNOSTIC INDEX; AGGRESSIVE NON-HODGKIN; HIGH-DOSE CHEMOTHERAPY; HIGH-RISK PATIENTS; BONE-MARROW-TRANSPLANTATION; SOUTHWEST-ONCOLOGY-GROUP; CHOP-LIKE CHEMOTHERAPY;

D O I：

10.1111/imj.15533

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype, accounting for 30-40% of lymphoma diagnoses. Although aggressive, cure is achievable in approximately 60% of cases with primary chemoimmunotherapy, and in a further substantial minority by salvage therapy and autologous stem cell transplantation. Despite promising activity in early phase clinical trials, no intensified or novel treatment regimen has improved outcomes over R-CHOP21 in randomised studies. However, there remain several areas of controversy including the most appropriate prognostic markers, central nervous system prophylaxis and the optimal treatment for patients with high-risk disease. This position statement presents an evidence-based synthesis of the literature for application in Australasian practice.

引用

页码：1609 / 1623

页数：15

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