A miniature confocal optical scanning microscope for endoscope

被引:8
作者
Murakami, K [1 ]
机构
[1] OLYMPUS CORP, Hachioji, Tokyo 1928512, Japan
来源
MOEMS DISPLAY AND IMAGING SYSTEMS III | 2005年 / 5721卷
关键词
confocal microscope; MEMS gimbal scanner; silicon nitride hinges; real time imaging;
D O I
10.1117/12.597342
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
We have developed a unique miniature confocal optical scanning microscope as an endoscopic application and successfully obtained a real time image. The confocal microscope can observe the longitudinal direction of a scanning head including the electrostatic 2-D MEMS scanner and an aspherical objective lens. Waterproof packaging of the scanning head is accomplished. The MEMS scanner and the objective lens in the head are assembled precisely and compactly. The MEMS scanner has a gimbal structure and the mirror flatness and Q factor are controlled by a stress-controlled silicon nitride. The scan angle of 12deg., the mirror flatness of 80nm(PV) and the mirror reflectance of over 85% are achieved. The diameter and length of the scanning head are 3.3mm and 8mm, respectively and it can insert into a channel of the endoscope. The lateral resolution of 0.5um, the depth resolution of 2.9um, the field of view of 100*75um and over 20/s of frame rate needed for the in-vivo inspection was achieved.
引用
收藏
页码:119 / 131
页数:13
相关论文
共 50 条
[41]   THREE-DIMENSIONAL MICROSCOPY OF BIOPSIES WITH A HANDHELD CONFOCAL MICROSCOPE [J].
Piyawattanametha, Wibool .
2015 INTERNATIONAL CONFERENCE ON OPTICAL MEMS AND NANOPHOTONICS (OMN), 2015,
[42]   MONITORING OF MATERIAL SURFACE POLISHING PROCEDURE USING CONFOCAL MICROSCOPE [J].
Dudikova, Michaela ;
Kytyr, Daniel ;
Doktor, Tomas ;
Jirousek, Ondrej .
CHEMICKE LISTY, 2011, 105 :S790-S791
[43]   Confocal microscope method for curvature radius measurement of small lens [J].
Liu Qian ;
Yang Weichuan ;
Wu Pengyue ;
Yuan Daocheng .
6TH INTERNATIONAL SYMPOSIUM ON ADVANCED OPTICAL MANUFACTURING AND TESTING TECHNOLOGIES: OPTICAL TEST AND MEASUREMENT TECHNOLOGY AND EQUIPMENT, 2012, 8417
[44]   Virtual Biopsies with Handheld Dual-Axis Confocal Microscope [J].
Piyawattanametha, Wibool .
WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2018, VOL 2, 2019, 68 (02) :805-808
[45]   Theory of confocal fluorescence imaging in the programmable array microscope (PAM) [J].
Verveer, PJ ;
Hanley, QS ;
Verbeek, PW ;
Van Vliet, LJ ;
Jovin, TM .
JOURNAL OF MICROSCOPY, 1998, 189 :192-198
[46]   Confocal multipoint multiphoton excitation microscope with microlens and pinhole arrays [J].
Fujita, K ;
Nakamura, O ;
Kaneko, T ;
Oyamada, M ;
Takamatsu, T ;
Kawata, S .
OPTICS COMMUNICATIONS, 2000, 174 (1-4) :7-12
[47]   Expression of GFP in tumor cells and fluorescent examination by confocal microscope [J].
Jin, Y ;
Xing, D ;
Xu, CY .
INTERNATIONAL WORKSHOP ON PHOTONICS AND IMAGING IN BIOLOGY AND MEDICINE, 2001, 4536 :214-218
[48]   Nonlinear distortion image correction from confocal microscope based on interpolation [J].
Bao X. ;
Dai S. ;
Guo C. ;
Lv S. ;
Shen C. ;
Liu Z. .
Hongwai yu Jiguang Gongcheng/Infrared and Laser Engineering, 2017, 46 (11)
[49]   Measurement of inhomogeneous absorptive organic media with polarization interferometric confocal microscope [J].
Fujita, Kohei ;
Egami, Chikara .
OPTICAL REVIEW, 2015, 22 (03) :410-414
[50]   Confocal microscope analysis and tridimensional reconstruction of papillary thyroid carcinoma nuclei [J].
Papotti, M ;
Manazza, AD ;
Chiarle, R ;
Bussolati, G .
VIRCHOWS ARCHIV, 2004, 444 (04) :350-355