SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL IMIDAZOLE DERIVATIVES AS POTENT ANTICONVULSANT AGENTS

被引：0
|
作者：
Mohammad, Noor [1 ]
Tabassum, Ruby [1 ]
Kishor, Brajnandan [2 ]
Srivastava, Neha [1 ]
Yogi, Bhumika [1 ]
Sinha, Anshuman [2 ]
Gupta, Sujeet K. [1 ]
机构：
[1] Hygia Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Lucknow 206020, Uttar Pradesh, India
[2] Hygia Inst Pharmaceut Educ & Res, Dept Pharmacol, Lucknow 206020, Uttar Pradesh, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 27卷 / 02期
关键词：
Imidazole; Anticonvulsant; Schiff base; Maximal electroshock method; ANTIINFLAMMATORY ACTIVITIES; DESIGN;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this study, we have made an attempt to synthesize novel imidazole derivatives (2a-h) and evaluate them for anticonvulsant activity using maximal electroshock method (MES). In the first step, substituted amines were allowed to react with substituted benzaldehyde in an equimolar amount with glacial acetic acid to form various substituted Schiff's base intermediate (1a-h). Schiff's base on treatment with benzil in the presence of ammonium acetate afforded corresponding imidazole derivatives (2a-h). The structure of the final analogs has been confirmed on the basis of elemental analysis, Fourier transform infrared spectroscopy (FT-IR), H-1 nuclear magnetic resonance (NMR), C-13 NMR, and mass spectra. Among all synthesized compounds, compounds 2a, 2f, and 2b were found to be most potent in comparison with standard phenytoin. [GRAPHICS]
引用
收藏
页码：137 / 142
页数：6
相关论文
共 50 条
  • [41] Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents
    Majcher, Urszula
    Klejborowska, Greta
    Kaik, Magdalena
    Maj, Ewa
    Wietrzyk, Joanna
    Moshari, Mahshad
    Preto, Jordane
    Tuszynski, Jack A.
    Huczynski, Adam
    CELLS, 2018, 7 (11)
  • [42] Synthesis, characterization and pharmacological evaluation of (E)-N′-(substituted-benzylidene)isonicotinohydrazide derivatives as potent anticonvulsant agents
    Manav Malhotra
    Vikramdeep Monga
    Sagun Sharma
    Jainendra Jain
    Abdul Samad
    James Stables
    Aakash Deep
    Medicinal Chemistry Research, 2012, 21 : 2145 - 2152
  • [43] Imidazole-1,2,4-oxadiazole-piperazine hybrids as potent anticancer agents: Synthesis, biological evaluation and molecular docking☆
    Nagineni, Devendra
    Murugesan, Periyasamy
    Abburi, Naga Pranathi
    Bollikanda, Rakesh Kumar
    Sridhar, Balasubramanian
    Tangutur, Anjana Devi
    Kantevari, Srinivas
    BIOORGANIC CHEMISTRY, 2025, 156
  • [44] Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors
    Lv, Peng-Cheng
    Wang, Kai-Rui
    Yang, Ying
    Mao, Wen-Jun
    Chen, Jin
    Xiong, Jing
    Zhu, Hai-Liang
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (23) : 6750 - 6754
  • [45] Synthesis and biological evaluation of β-lactams as potent antidiabetic agents
    Shaheen, Salma
    Arshad, Jahan Zaib
    Haider, Mansoor
    Ashraf, Adnan
    Ahmad, Muhammad Mahboob
    Ashfaq, Muhammad
    Ismail, Mostafa A.
    Najam, Tayyaba
    Shah, Syed Shoaib Ahmad
    NEW JOURNAL OF CHEMISTRY, 2024, 48 (46) : 19427 - 19440
  • [46] Novel 1,4 benzothiazine 3-one derivatives as anticonvulsant agents: Design, synthesis, biological evaluation and computational studies
    Ataollahi, Elaheh
    Solhjoo, Aida
    Rezaei, Zahra
    Behrouz, Marzieh
    Heidari, Reza
    Shahbazi, Mohammad Reza
    Foroozanad, Reza
    Zamani, Leila
    Khabnadideh, Soghra
    Emami, Leila
    COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2023, 104
  • [47] Application of a Deep Eutectic Solvent for the Synthesis of Novel Imidazole-Containing Quinazoline Derivatives as Potent Cytotoxic Agents
    Moghadam, Fatemeh Azmian
    Dabirian, Sara
    Tavani, Amin Ebrahimi
    Alipour, Parisa
    Mojabi, Mohammad
    Evazalipour, Mehdi
    Yousefbeyk, Fatemeh
    Ghasemi, Saeed
    PHARMACEUTICAL SCIENCES, 2024, 30 (02) : 215 - 228
  • [48] Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition
    Xu, Shaohua
    Fan, Ruolan
    Wang, Lu
    He, Weishen
    Ge, Haixia
    Chen, Hailan
    Xu, Wen
    Zhang, Jian
    Xu, Wei
    Feng, Yaqian
    Fan, Zhimin
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 37 (01) : 236 - 251
  • [49] Structure based design, synthesis, and biological evaluation of imidazole derivatives
    Daraji, Drashti G.
    Rajani, Dhanji P.
    Rajani, Smita D.
    Pithawala, Edwin A.
    Jayanthi, Sivaraman
    Patel, Hitesh D.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 36
  • [50] Synthesis, Characterization and Biological Evaluation of Quinoline Based Imidazole Derivatives
    Parab, R. H.
    Chudasama, C. J.
    Patel, H. N.
    Dixit, B. C.
    Desai, D. J.
    ASIAN JOURNAL OF CHEMISTRY, 2010, 22 (10) : 7641 - 7647
12345