SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL IMIDAZOLE DERIVATIVES AS POTENT ANTICONVULSANT AGENTS

被引：0

作者：

Mohammad, Noor ^{[1
]}

Tabassum, Ruby ^{[1
]}

Kishor, Brajnandan ^{[2
]}

Srivastava, Neha ^{[1
]}

Yogi, Bhumika ^{[1
]}

Sinha, Anshuman ^{[2
]}

Gupta, Sujeet K. ^{[1
]}

机构：

[1] Hygia Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Lucknow 206020, Uttar Pradesh, India

[2] Hygia Inst Pharmaceut Educ & Res, Dept Pharmacol, Lucknow 206020, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 27卷 / 02期

关键词：

Imidazole; Anticonvulsant; Schiff base; Maximal electroshock method; ANTIINFLAMMATORY ACTIVITIES; DESIGN;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, we have made an attempt to synthesize novel imidazole derivatives (2a-h) and evaluate them for anticonvulsant activity using maximal electroshock method (MES). In the first step, substituted amines were allowed to react with substituted benzaldehyde in an equimolar amount with glacial acetic acid to form various substituted Schiff's base intermediate (1a-h). Schiff's base on treatment with benzil in the presence of ammonium acetate afforded corresponding imidazole derivatives (2a-h). The structure of the final analogs has been confirmed on the basis of elemental analysis, Fourier transform infrared spectroscopy (FT-IR), H-1 nuclear magnetic resonance (NMR), C-13 NMR, and mass spectra. Among all synthesized compounds, compounds 2a, 2f, and 2b were found to be most potent in comparison with standard phenytoin. [GRAPHICS]

引用

页码：137 / 142

页数：6

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