Development of the gut microbiota in infancy and its impact on health in later life

被引：405

作者：

Tanaka, Masaru ^{[1
]}

Nakayama, Jiro ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch, Fac Agr, Dept Biosci & Biotechnol, Fukuoka, Japan

来源：

ALLERGOLOGY INTERNATIONAL | 2017年 / 66卷 / 04期

基金：

日本学术振兴会;

关键词：

Allergy; Bifidobacterium; Gut microbiota; Hygiene hypothesis; Infants; LACTOBACILLUS-GASSERI SBT2055; REGULATORY T-CELLS; BREAST-MILK; 1ST YEAR; INTESTINAL MICROBIOTA; COMMENSAL BACTERIA; FOOD SENSITIZATION; IMMUNE-RESPONSES; ALLERGY; DIVERSITY;

D O I：

10.1016/j.alit.2017.07.010

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Gut microbial ecology and function are dynamic in infancy, but are stabilized in childhood. The 'new friends' have a great impact on the development of the digestive tract and host immune system. In the first year of life, especially, the gut microbiota dramatically changes through interactions with the developing immune system in the gut. The process of establishing the gut microbiota is affected by various environmental factors, with the potential to be a main determinant of life-long health. In this review, we summarize recent findings regarding gut microbiota establishment, including the importance of various factors related to the development of the immune system and allergic diseases later in life. Copyright (C) 2017, Japanese Society of Allergology. Production and hosting by Elsevier B.V.

引用

页码：515 / 522

页数：8

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