Enzymatic synthesis of fluorinated mechanistic probes for sialidases and sialyltransferases

被引：59

作者：

Chokhawala, Harshal A. ^{[1
]}

Cao, Hongzhi ^{[1
]}

Yu, Hai ^{[1
]}

Chen, Xi ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 35期

关键词：

D O I：

10.1021/ja072687u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general, convenient, and efficient enzymatic approach for producing fluorinated mechanistic probes for sialidases and sialyltransferases is described. Other than the reported sialyltransferase inhibitor CMP-3F(axial)Neu5Ac, CIVIP-3F (equatorial)Sia derivatives (in which Sia is Neu5Ac or Neu5Gc) have been synthesized along with CMP-3F (axial)Neu5Gc and CMP-3F(axia/)KDN as novel inhibitors and important mechanistic probes for sialyltransferases. 3-Fluoro-sialosides have been enzymatically synthesized and could be used as potential inhibitors and mechanistic probes for sialidases and as probes for sialic acid-binding proteins.

引用

页码：10630 / +

页数：3

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