The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy

被引：10

作者：

Behnam, Mohammad ^{[1
]}

Motamedzadeh, Alireza ^{[2
]}

Aalinezhad, Marzieh ^{[3
]}

Dadgostar, Ehsan ^{[4
,5
]}

Noshabad, Fatemeh Zahra Rashidi ^{[1
]}

Pourfridoni, Mohammad ^{[6
]}

Raei, Maedeh ^{[7
]}

Mirzaei, Hamed ^{[8
]}

Aschner, Michael ^{[9
]}

Tamtaji, Omid Reza ^{[10
,11
]}

机构：

[1] Kashan Univ Med Sci, Student Res Comm, Kashan, Iran

[2] Kashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran

[3] Isfahan Univ Med Sci, Sch Med, Dept Radiol, Esfahan, Iran

[4] Isfahan Univ Med Sci, Behav Sci Res Ctr, Esfahan, Iran

[5] Isfahan Univ Med Sci, Student Res Comm, Esfahan, Iran

[6] Jiroft Univ Med Sci, Student Res Comm, Jiroft, Iran

[7] Islamic Azad Univ, Fac Med, Sari Branch, Sari, Iran

[8] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Inst Basic Sci, Kashan, Iran

[9] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

[10] Univ Tehran Med Sci, Electrophysiol Res Ctr, Neurosci Inst, Tehran, Iran

[11] Univ Tehran Med Sci, Sch Med, Dept Physiol, Tehran, Iran

来源：

MOLECULAR BIOLOGY REPORTS | 2022年 / 49卷 / 11期

关键词：

Aquaporin; 4; Glioma; Glioblastoma; Astrocytoma; Meningioma; CENTRAL-NERVOUS-SYSTEM; CANCER-ASSOCIATED FIBROBLASTS; CELL-PROLIFERATION; PERITUMORAL EDEMA; GLIOMA; EXPRESSION; MIGRATION; APOPTOSIS; INVASION; GLIOBLASTOMA;

D O I：

10.1007/s11033-022-07656-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO-Kyn-AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved.

引用

页码：10609 / 10615

页数：7

共 83 条

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