Regio- and Enantioselective Iridium-Catalyzed Allylation of Thiophenol: Synthesis of Enantiopure Allyl Phenyl Sulfides

被引：42
|
作者：
Zheng, Shengcai [1 ]
Gao, Ning [1 ]
Liu, Wei [1 ]
Liu, Dongge [1 ]
Zhao, Xiaoming [1 ]
Cohen, Theodore [2 ]
机构：
[1] Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China
[2] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 20期
关键词：
PHOSPHORAMIDITE LIGAND; ASYMMETRIC-SYNTHESIS; SUBSTITUTION; ALKYLATION; ETHERIFICATION; CARBONATES; COMPLEXES; ALCOHOLS;
D O I：
10.1021/ol101915b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly regio- and enantioselective allylic alkylation of sodium thiophenoxide has been realized by [Ir(COD)CI](2)/phosphoramidite along with CsF as an additive, producing highly enantioenriched allyl phenyl sulfide compounds with up to 99% ee.
引用
收藏
页码：4454 / 4457
页数：4
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