G-Quadruplex Assembly by Ribosomal DNA: Emerging Roles in Disease Pathogenesis and Cancer Biology

被引：17

作者：

Datta, Arindam ^{[1
]}

Pollock, Kevin J. ^{[2
]}

Kormuth, Karen A. ^{[2
]}

Brosh, Robert M., Jr. ^{[1
]}

机构：

[1] Natl Inst Aging, Translat Gerontol Branch, Baltimore, MD 21224 USA

[2] Bethany Coll, Dept Biol, Bethany, WV 26032 USA

来源：

CYTOGENETIC AND GENOME RESEARCH | 2021年 / 161卷 / 6-7期

关键词：

Ribosomal DNA; G-quadruplex; Helicase; Aging; Cancer; DNA damage; Genomic instability; Transcription; RNA-POLYMERASE-II; SYNDROME GROUP-A; GROUP-B PROTEIN; COCKAYNE-SYNDROME; TRANSCRIPTION FACTOR; REPAIR; HELICASE; REPLICATION; ELONGATION; GENES;

D O I：

10.1159/000516394

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Unique repetitive elements of the eukaryotic genome can be problematic for cellular DNA replication and transcription and pose a source of genomic instability. Human ribosomal DNA (rDNA) exists as repeating units clustered together on several chromosomes. Understanding the molecular mechanisms whereby rDNA interferes with normal genome homeostasis is the subject of this review. We discuss the instability of rDNA as a driver of senescence and the important roles of helicases to suppress its deleterious effects. The propensity of rDNA that is rich in guanine bases to form G-quadruplexes (G4) is discussed and evaluated in disease pathogenesis. Targeting G4 in the ribosomes and other chromosomal loci may represent a useful synthetic lethal approach to combating cancer.

引用

页码：285 / 296

页数：12

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