Discovery of a Highly Potent Anti-inflammatory Epoxyisoprostane-Derived Lactone

被引：26

作者：

Egger, Julian ^{[1
]}

Bretscher, Peter ^{[2
]}

Freigang, Stefan ^{[2
]}

Kopf, Manfred ^{[2
]}

Carreira, Erick M. ^{[1
]}

机构：

[1] ETH, Lab Organ Chem, CH-8093 Zurich, Switzerland

[2] ETH, Inst Integrat Biol, CH-8093 Zurich, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 50期

关键词：

ALPHA; BETA-UNSATURATED CARBONYL-COMPOUNDS; CYCLOPENTENONE PROSTAGLANDINS; OXIDIZED PHOSPHOLIPIDS; BIOLOGICAL-ACTIVITIES; CONJUGATE REDUCTION; PATHWAY;

D O I：

10.1021/ja509892u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Epoxyisoprostanes EI (1) and EC (2) are effective inhibitors of the secretion of proinflammatory cytokines IL-6 and IL-12. In detailed studies toward the investigation of the molecular mode of action of these structures, a highly potent lactone (3) derived from 1 was identified. The known isoprostanoids 1 and 2 are most likely precursors of 3, the product of facile intramolecular reaction between the epoxide with the carboxylic acid in 2.

引用

收藏

页码：17382 / 17385

页数：4

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