NIR-II fluorescence imaging guided tumor-specific NIR-II photothermal therapy enhanced by starvation mediated thermal sensitization strategy

被引:99
作者
Dai, Yeneng [1 ]
Sun, Zhiquan [1 ]
Zhao, Honghai [1 ]
Qi, Dashan [1 ]
Li, Xiangyu [1 ]
Gao, Diya [3 ]
Li, Meixing [1 ]
Fan, Quli [1 ]
Shen, Qingming [1 ]
Huang, Wei [1 ,2 ]
机构
[1] Univ Posts & Telecommun, Inst Adv Mat IAM, State Key Lab Organ Elect & Informat Displays & J, Nanjing 210023, Peoples R China
[2] Northwestern Polytech Univ, Frontiers Sci Ctr Flexible Elect FSCFE, MIIT Key Lab Flexible Elect KLoFE, Xian 710072, Peoples R China
[3] Jiangsu Simcere Diagnost Co Ltd, State Key Lab Translat Med & Innovat Drug Dev, Nanjing, Peoples R China
基金
中国国家自然科学基金;
关键词
Second near infrared light; Photothermal therapy; Fluorescence imaging; Starvation therapy; Glycolysis metabolism; Thermal sensitization; POLYMER NANOPARTICLES; METABOLISM; CELLS;
D O I
10.1016/j.biomaterials.2021.120935
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Photothermal therapy (PTT) is hampered by limited light penetration depth and cell thermoresistance induced by over-expressed heat shock proteins (HSPs). Herein, we proposed a tumor-specific enhanced NIR-II PTT through the starvation mediated thermal sensitization strategy. A semiconducting polymer with superior NIR-II fluorescence imaging (FI) performance and NIR-II PTT efficacy was synthesized and encapsulated into folate modified liposomes, together with a glycolysis inhibitor, 2-deoxy-D-glucose (2DG). Upon specifically targeting folate receptors and guidance of NIR-II FI, spatiotemporal 2DG release could be achieved by the trigger of NIR-II photothermal effect. The released 2DG could not only deplete the energy supply of tumor cells by inhibiting tumor anaerobic glycolysis, but also decrease the ATP levels and hamper the production of HSPs, ultimately enhancing the tumor thermal sensitivity toward PTT. Owing to the sensitization effect of 2DG, tumor cells with overexpressed folate receptors could be significantly damaged by NIR-II PTT with an enhanced therapeutic efficiency. The work provided a promising strategy for specific starvation/NIR-II PTT synergistic therapy towards tumors.
引用
收藏
页数:12
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