ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment

被引：44

作者：

Au-Yeung, Chi-Lam ^{[1
,2
]}

Yeung, Tsz-Lun ^{[1
,2
]}

Achreja, Abhinav ^{[3
]}

Zhao, Hongyun ^{[3
]}

Yip, Kay-Pong ^{[4
]}

Kwan, Suet-Ying ^{[1
]}

Onstad, Michaela ^{[1
]}

Sheng, Jianting ^{[5
,6
]}

Zhu, Ying ^{[5
,6
]}

Baluya, Dodge L. ^{[7
]}

Co, Ngai-Na ^{[1
]}

Rynne-Vidal, Angela ^{[1
]}

Schmandt, Rosemarie ^{[1
,2
]}

Anderson, Matthew L. ^{[8
]}

Lu, Karen H. ^{[1
,2
]}

Wong, Stephen T. C. ^{[5
,6
]}

Nagrath, Deepak ^{[3
]}

Mok, Samuel C. ^{[1
,2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol & Reprod Med, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, UTHlth Grad Sch Biomed Sci Houston, Houston, TX 77030 USA

[3] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[4] Univ S Florida, Dept Mol Pharmacol & Physiol, Tampa, FL 33620 USA

[5] Weill Cornell Med, Dept Syst Med & Bioengn, Houston Methodist Res Inst, Houston, TX 77030 USA

[6] Houston Methodist Canc Ctr, Ctr Precis Oncol, Houston, TX 77030 USA

[7] Univ Texas MD Anderson Canc Ctr, Dept Diagnost Imaging Intervent Radiol, Houston, TX 77030 USA

[8] Baylor Coll Med, Duncan L Comprehens Canc Ctr, Dept Obstet & Gynecol, Houston, TX 77030 USA

来源：

NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

OVERWEIGHT; OMENTIN-1; ADIPOKINE; INSULIN;

D O I：

10.1038/s41467-020-17383-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Advanced ovarian cancer usually spreads to the omentum. However, the omental cell-derived molecular determinants modulating its progression have not been thoroughly characterized. Here, we show that circulating ITLN1 has prognostic significance in patients with advanced ovarian cancer. Further studies demonstrate that ITLN1 suppresses lactotransferrin's effect on ovarian cancer cell invasion potential and proliferation by decreasing MMP1 expression and inducing a metabolic shift in metastatic ovarian cancer cells. Additionally, ovarian cancer-bearing mice treated with ITLN1 demonstrate marked decrease in tumor growth rates. These data suggest that downregulation of mesothelial cell-derived ITLN1 in the omental tumor microenvironment facilitates ovarian cancer progression. Advanced ovarian cancer usually spreads to the omentum. Here, the authors show that circulating intelectin-1 (ITLN1) has prognostic significance in patients with advanced ovarian cancer, and that mesothelial cell-derived ITLN1 in the omental tumor microenvironment suppresses ovarian cancer progression.

引用

页数：16

共 35 条

[21] Human neutrophil lactoferrin trans-activates the matrix metalloproteinase 1 gene through stress-activated MAPK signaling modules [J].

Oh, SM ;

Hahm, DH ;

Kim, IH ;

Choi, SY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (45) :42575-42579

[22] Cell migration: Integrating signals from front to back [J].

Ridley, AJ ;

Schwartz, MA ;

Burridge, K ;

Firtel, RA ;

Ginsberg, MH ;

Borisy, G ;

Parsons, JT ;

Horwitz, AR .

SCIENCE, 2003, 302 (5651) :1704-1709

[23] Mesothelial-to-mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer [J].

Rynne-Vidal, Angela ;

Au-Yeung, Chi Lam ;

Jimenez-Heffernan, Jose A. ;

Luisa Perez-Lozano, Maria ;

Cremades-Jimeno, Lucia ;

Barcena, Carmen ;

Cristobal-Garcia, Ignacio ;

Fernandez-Chacon, Concepcion ;

Yeung, Tsz Lun ;

Mok, Samuel C. ;

Sandoval, Pilar ;

Lopez-Cabrera, Manuel .

JOURNAL OF PATHOLOGY, 2017, 242 (02) :140-151

[24] Effects of aerobic training on serum omentin-1 and cardiometabolic risk factors in overweight and obese men [J].

Saremi, A. ;

Asghari, M. ;

Ghorbani, A. .

JOURNAL OF SPORTS SCIENCES, 2010, 28 (09) :993-998

[25] Cancer statistics, 2020 [J].

Siegel, Rebecca L. ;

Miller, Kimberly D. ;

Jemal, Ahmedin .

CA-A CANCER JOURNAL FOR CLINICIANS, 2020, 70 (01) :7-30

[26] Mammalian lactoferrin receptors:: structure and function [J].

Suzuki, YA ;

Lopez, V ;

Lönnerdal, B .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2005, 62 (22) :2560-2575

[27] Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome - Ex vivo and in vivo regulation of omentin-1 by insulin and glucose [J].

Tan, Bee K. ;

Adya, Raghu ;

Farhatullah, S. ;

Lewandowski, Kris C. ;

O'Hare, Paul ;

Lehnert, Hendrik ;

Randeva, Harpal S. .

DIABETES, 2008, 57 (04) :801-808

[28] Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis [J].

Templeton, Arnoud J. ;

McNamara, Mairead G. ;

Seruga, Bostjan ;

Vera-Badillo, Francisco E. ;

Aneja, Priya ;

Ocana, Alberto ;

Leibowitz-Amit, Raya ;

Sonpavde, Guru ;

Knox, Jennifer J. ;

Tran, Ben ;

Tannock, Ian F. ;

Amir, Eitan .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2014, 106 (06)

[29]

Thompson MS, 2009, MINERVA MED, V100, P357

[30] Inhibition of tumor growth by recombinant adenovirus containing human lactoferrin through inducing tumor cell apoptosis in mice bearing EMT6 breast cancer [J].

Wang, Jianjie ;

Li, Qingwang ;

Ou, Yetao ;

Han, Zengsheng ;

Li, Kun ;

Wang, Peijun ;

Zhou, Shaobo .

ARCHIVES OF PHARMACAL RESEARCH, 2011, 34 (06) :987-995

← 1 2 3 4 →