Ancient Genomes Reveal the Evolutionary History and Origin of Cashmere-Producing Goats in China

被引：58

作者：

Cai, Yudong ^{[1
]}

Fu, Weiwei ^{[1
]}

Cai, Dawei ^{[2
]}

Heller, Rasmus ^{[3
]}

Zheng, Zhuqing ^{[1
]}

Wen, Jia ^{[1
]}

Li, Hui ^{[1
,4
]}

Wang, Xiaolong ^{[1
]}

Alshawi, Akil ^{[5
,6
]}

Sun, Zhouyong ^{[7
]}

Zhu, Siqi ^{[2
]}

Wang, Juan ^{[8
]}

Yang, Miaomiao ^{[7
]}

Hu, Songmei ^{[7
]}

Li, Yan ^{[1
]}

Yang, Zhirui ^{[1
]}

Gong, Mian ^{[1
]}

Hou, Yunan ^{[1
]}

Lan, Tianming ^{[9
,10
]}

Wu, Kui ^{[11
,12
]}

Chen, Yulin ^{[1
]}

Jiang, Yu ^{[1
]}

Wang, Xihong ^{[1
]}

机构：

[1] Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Yangling, Shaanxi, Peoples R China

[2] Jilin Univ, Res Ctr Chinese Frontier Archaeol, Changchun, Peoples R China

[3] Univ Copenhagen, Dept Biol, Sect Computat & RNA Biol, Copenhagen, Denmark

[4] Guangxi Univ, State Key Lab Conservat & Utilizat Subtrop Agrobi, Nanning, Peoples R China

[5] Univ Nottingham, Fac Med & Hlth Sci, Sch Life Sci, Nottingham, England

[6] Univ Baghdad, Coll Vet Med, Dept Internal & Prevent Med, Iraqi Minist Higher Educ & Sci Res, Baghdad, Iraq

[7] Shaanxi Acad Archaeol, Xian, Peoples R China

[8] Henan Prov Inst Cultural Heritage & Archaeol, Zhengzhou, Peoples R China

[9] BGI Shenzhen, Build 11, Shenzhen, Peoples R China

[10] Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, Copenhagen, Denmark

[11] BGI Shenzhen, China Natl GeneBank Shenzhen, Shenzhen, Peoples R China

[12] BGI Shenzhen, Canc Inst, BGI Res, Shenzhen, Peoples R China

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2020年 / 37卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Chinese goats; ancient DNA; population genomics; adaptation; FGF5; EDA2R; FGF5;

D O I：

10.1093/molbev/msaa103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Goats are one of the most widespread farmed animals across the world; however, their migration route to East Asia and local evolutionary history remain poorly understood. Here, we sequenced 27 ancient Chinese goat genomes dating from the Late Neolithic period to the Iron Age. We found close genetic affinities between ancient and modern Chinese goats, demonstrating their genetic continuity. We found that Chinese goats originated from the eastern regions around the Fertile Crescent, and we estimated that the ancestors of Chinese goats diverged from this population in the Chalcolithic period. Modern Chinese goats were divided into a northern and a southern group, coinciding with the most prominent climatic division in China, and two genes related to hair follicle development, FGF5 and EDA2R, were highly divergent between these populations. We identified a likely causal de novo deletion near FGF5 in northern Chinese goats that increased to high frequency over time, whereas EDA2R harbored standing variation dating to the Neolithic. Our findings add to our understanding of the genetic composition and local evolutionary process of Chinese goats.

引用

页码：2099 / 2109

页数：11

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