A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia

被引：168
作者：
Goff, DC
Leahy, L
Berman, I
Posever, T
Herz, L
Leon, AC
Johnson, SA
Lynch, G
机构：
[1] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92717 USA
[2] Cortex Pharmaceut, Irvine, CA USA
[3] Cornell Univ, Weill Med Coll, Dept Psychiat, New York, NY USA
[4] Vet Affairs Med Ctr, Bedford, MA USA
[5] Tufts Univ, Sch Med, Boston, MA 02111 USA
[6] Lemmuel Shattuck Hosp, Boston, MA USA
[7] Taunton State Hosp, Taunton, MA USA
[8] Harvard Univ, Sch Med, Boston, MA USA
[9] Massachusetts Gen Hosp, Psychiat Serv, Boston, MA 02114 USA
来源：
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY | 2001年 / 21卷 / 05期
关键词：
D O I：
10.1097/00004714-200110000-00005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
CX516, a positive modulator of the glutamatergic alpha -amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor, improves performance in tasks requiring learning and memory in animals. CX516 was added to clozapine in 4-week, placebo-controlled, dose-finding (N = 6) and fixed-dose (N = 13) trials. CX516 was tolerated well and was associated with moderate to large, between-group effect sizes compared with placebo, representing improvement in measures of attention and memory. These preliminary results suggest that CX516 and other "ampakines" hold promise for the treatment of schizophrenia.
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收藏
页码：484 / 487
页数：4
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