Coronary sinus retroperfusion during acute experimental coronary artery occlusion

Background This study was planned to show the effect of retroperfusion and cardiopulmonary bypass on myocardial hemodynamic recovery. Methods, Eighteen dogs entered this study, After, left anterior descending artery (LAD) was dissected and occluded, the animals were divided into three equal groups; Group I: retrograde coronary sinus perfusion, group II: cardiopulmonary bypass and retrograde coronary sinus perfusion, Group III: control group, left anterior descending artery occlusion only, Results. In Group III, deterioration of the hemodynamic values progressed parallel with the degree of ischemic damage but in Group I, hemodynamic parameters were better because of the retrograde coronary sinus perfusion and minimally affected by the reperfusion, In Group II, at the end of the cardiopulmonary bypass minimal myocardial damage was observed. Conclusions. There is no statistical difference between Group I and II if we examine the data that was taken after reperfusion although myocardial performance was better in Group II.