Pain during topical photodynamic therapy - comparing methyl aminolevulinate (Metvix®) to aminolaevulinic acid (Ameluz®); an intra-individual clinical study

被引：15

作者：

Yazdanyar, Shiva ^{[1
,2
]}

Zarchi, Kian ^{[1
,2
]}

Jemec, Gregor B. E. ^{[1
,2
]}

机构：

[1] Roskilde Hosp, Dept Dermatol, Kogevej 7-13, DK-4000 Roskilde, Denmark

[2] Univ Copenhagen, Hlth Sci Fac, Copenhagen, Denmark

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2017年 / 20卷

关键词：

Actinic keratosis; Aminolaevulinic acid; Aminolaevulinic acid methylester; Pain; Photodynamic; QUALITY-OF-LIFE; COLD-AIR ANALGESIA; DOUBLE-BLIND; 5-AMINOLEVULINIC ACID; ACTINIC KERATOSES; RELIEF; GEL; EFFICACY; DISEASE;

D O I：

10.1016/j.pdpdt.2017.07.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Actinic keratoses are often treated by photodynamic therapy. However, the main side effect of this treatment is pain during and shortly after illumination. Objectives: To evaluate, in an intra-individual study, whether the pain response differ in treatment of actinic keratoses in scalp and forhead, using branded methyl aminolevulinate (MAL) and aminolaevulinic acid (ALA). Materials and methods: Patients with mild to moderate actinic keratoses on forehead and scalp were treated with methyl aminolaevulinate (MAL)-PDT and aminolaevulinic acid (ALA)-PDT on two similar areas of forehead and scalp. The pain response were measured using visual analogue scale ranging from 0 to 10 during the illumination and 30 min after the treatment. Results: Fourteen patients completed treatment to MAL and ALA-PDT. We found no significant difference in pain intensity between MAL and ALA-PDT, neither during the treatment (p-value = 1) nor 30 min after the treatment (p-value of 0.19). Conclusions: This infra-individual study demonstrate no significant difference between the pain response during PDT using methyl aminolevulinate and aminolaevulinic acid.

引用

页码：6 / 9

页数：4

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