Diastolic dysfunction and pulmonary hypertension in sickle cell anemia: Is there a role for L-carnitine treatment?

被引：14

作者：

El-Beshlawy, A

Abd El Raouf, E

Mostafa, F

Talaat, M

Isma'eel, H

Aoun, E

Hoffbrand, AV

Taher, A

机构：

[1] Cairo Univ, Fac Med, Dept Pediat, Cairo, Egypt

[2] Amer Univ Beirut, Med Ctr, Dept Internal Med, Beirut, Lebanon

[3] Royal Free Hosp, Dept Haematol, London NW3 2QG, England

来源：

ACTA HAEMATOLOGICA | 2006年 / 115卷 / 1-2期

关键词：

L-carnitine; pulmonary hypertention; sickle cell anemia;

D O I：

10.1159/000089472

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Clinical manifestations of cardiovascular abnormalities in patients with sickle cell (SC) anemia are well documented. Many variables were assessed in our study before and after administration of L-carnitine to randomly selected 37 SC disease (SCD) children for a period of 6 months. Variables such as weight, height, serum ferritin levels, units of blood transfused and the number of veno-occlusive crises all showed significant improvement after the 6 months of therapy with L-carnitine. Our study also showed that cardiac diastolic function and pulmonary hypertention are common in pediatric SCD patients. These two disorders showed some improvement after L-carnitine administration. Therefore, L-carnitine deserves a rigorous large-scale randomized clinical trial to evaluate its potential benefits as treatment for SCD patients with cardiac complications. Copyright (C) 2006 S. Karger AG, Basel.

引用

页码：91 / 96

页数：6

共 44 条

[1] ESTIMATION OF LEFT-VENTRICULAR FILLING PRESSURES USING 2-DIMENSIONAL AND DOPPLER-ECHOCARDIOGRAPHY IN ADULT PATIENTS WITH CARDIAC DISEASE - ADDITIONAL VALUE OF ANALYZING LEFT ATRIAL SIZE, LEFT ATRIAL EJECTION FRACTION AND THE DIFFERENCE IN DURATION OF PULMONARY VENOUS AND MITRAL FLOW VELOCITY AT ATRIAL CONTRACTION [J].