TBHP/TBAI-Mediated simple and efficient synthesis of 3,5-disubstituted and 1,3,5-trisubstituted 1H-1,2,4-triazoles via oxidative decarbonylation of aromatic aldehydes and testing for antibacterial activities

被引：11

作者：

Agisho, Habtamu Abebe ^{[1
]}

Esatu, Habdolo ^{[1
]}

Hairat, Suboot ^{[2
]}

Zaki, Mehvash ^{[3
]}

机构：

[1] Wachemo Univ, Dept Chem, POB 667, Hosanna, Ethiopia

[2] Wachemo Univ, Dept Biotechnol, POB 667, Hosanna, Ethiopia

[3] King Abdulaziz Univ, Dept Chem, POB 80203, Jeddah, Saudi Arabia

来源：

TETRAHEDRON LETTERS | 2020年 / 61卷 / 24期

关键词：

1H-1,2, 4-triazoles; Antibacterial activity; Radical trapping; TBHP; ANTIFUNGAL; CHROMONES;

D O I：

10.1016/j.tetlet.2020.151989

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The author has developed a simple, efficient and eco-friendly convenient general method for synthesis of 3,5-disubstituted-1,2,4-triazoles and 1,3,5-trisubstituted-1,2,4-triazoles from 3-monosubstituted-1,2,4-triazoles and 1,3-disubstituted-1,2,4-triazoles respectively using tetrabutylammonium iodide (TBAI) as catalyst and TBHP as oxidant under mid reaction conditions. This method provides structurally diverse 3,5-disubstituted 1,2,4-triazoes and 1,3,5-trisubstituted-1,2,4-triazoles in good to excellent yields. 3,5-Disubstituted 1,2,4-triazoes and 1,3,5-trisubstituted-1,2,4-triazoles derivatives are biologically and pharmaceutically active molecules, and therefore, this protocol could be of wide applications in medicinal chemistry and organic chemistry. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：7

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