The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS

被引：199
作者：
Kadowaki, Takashi [1 ,2 ]
Yamauchi, Toshimasa [1 ,3 ]
Kubota, Naoto [1 ,2 ,3 ]
机构：
[1] Univ Tokyo, Dept Metab Dis, Grad Sch Med, Tokyo, Japan
[2] Natl Inst Hlth & Nutr, Div Appl Nutr, Tokyo 162, Japan
[3] Univ Tokyo, Grad Sch Med, Dept Integrated Mol Sci Metab Dis, Tokyo, Japan
来源：
FEBS LETTERS | 2008年 / 582卷 / 01期
关键词：
adiponectin; adipoectin receptor; metabolic syndrome; AMP-activated protein kinase (AMPK); energy homeostasis; starvation gene;
D O I：
10.1016/j.febslet.2007.11.070
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Adiponectin is an abundantly expressed adipokine in adipose tissue and has direct insulin sensitizing activity. A decrease in the circulating levels of adiponectin by interactions between genetic factors and environmental factors causing obesity has been shown to contribute to the development of insulin resistance, type 2 diabetes, metabolic syndrome and atherosclerosis. In addition to its insulin sensitizing actions, adiponectin has central actions in the regulation of energy homeostasis. Adiponectin enhances AMP-activated protein kinase activity in the arcuate hypothalamus via its receptor AdipoR1 to stimulate food intake and decreases energy expenditure. We propose a hypothesis on the physiological role of adiponectin: a starvation gene in the course of evolution by promoting fat storage on facing the loss of adiposity. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：74 / 80
页数：7
相关论文
共 42 条
  • [31] Adiponectin acts in the brain to decrease body weight
    Qi, Y
    Takahashi, N
    Hileman, SM
    Patel, HR
    Berg, AH
    Pajvani, UB
    Scherer, PE
    Ahima, RS
    [J]. NATURE MEDICINE, 2004, 10 (05) : 524 - 529
  • [32] ROLE OF INSULIN RESISTANCE IN HUMAN-DISEASE
    REAVEN, GM
    [J]. DIABETES, 1988, 37 (12) : 1595 - 1607
  • [33] Cellular mechanisms of insulin resistance
    Shulman, GI
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (02) : 171 - 176
  • [34] Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells
    Spranger, J
    Verma, S
    Göhring, I
    Bobbert, T
    Seifert, J
    Sindler, AL
    Pfeiffer, A
    Hileman, SM
    Tschöp, M
    Banks, WA
    [J]. DIABETES, 2006, 55 (01) : 141 - 147
  • [35] The hormone resistin links obesity to diabetes
    Steppan, CM
    Bailey, ST
    Bhat, S
    Brown, EJ
    Banerjee, RR
    Wright, CM
    Patel, HR
    Ahima, RS
    Lazar, MA
    [J]. NATURE, 2001, 409 (6818) : 307 - 312
  • [36] Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity
    Tsuchida, A
    Yamauchi, T
    Ito, Y
    Hada, Y
    Maki, T
    Takekawa, S
    Kamon, J
    Kobayashi, M
    Suzuki, R
    Hara, K
    Kubota, N
    Terauchi, Y
    Froguel, P
    Nakae, J
    Kasuga, M
    Accili, D
    Tobe, K
    Ueki, K
    Nagai, R
    Kadowaki, T
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (29) : 30817 - 30822
  • [37] Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase
    Woods, A
    Azzout-Marniche, D
    Foretz, M
    Stein, SC
    Lemarchand, P
    Ferré, P
    Foufelle, F
    Carling, D
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (18) : 6704 - 6711
  • [38] AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
    Xue, Bingzhong
    Kahn, Barbara B.
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2006, 574 (01): : 73 - 83
  • [39] Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
    Yamauchi, T
    Kamon, J
    Ito, Y
    Tsuchida, A
    Yokomizo, T
    Kita, S
    Sugiyama, T
    Miyagishi, M
    Hara, K
    Tsunoda, M
    Murakami, K
    Ohteki, T
    Uchida, S
    Takekawa, S
    Waki, H
    Tsuno, NH
    Shibata, Y
    Terauchi, Y
    Froguel, P
    Tobe, K
    Koyasu, S
    Taira, K
    Kitamura, T
    Shimizu, T
    Nagai, R
    Kadowaki, T
    [J]. NATURE, 2003, 423 (6941) : 762 - 769
  • [40] The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    Yamauchi, T
    Kamon, J
    Waki, H
    Terauchi, Y
    Kubota, N
    Hara, K
    Mori, Y
    Ide, T
    Murakami, K
    Tsuboyama-Kasaoka, N
    Ezaki, O
    Akanuma, Y
    Gavrilova, O
    Vinson, C
    Reitman, ML
    Kagechika, H
    Shudo, K
    Yoda, M
    Nakano, Y
    Tobe, K
    Nagai, R
    Kimura, S
    Tomita, M
    Froguel, P
    Kadowaki, T
    [J]. NATURE MEDICINE, 2001, 7 (08) : 941 - 946
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