Genetic polymorphism and variability of chemical carcinogenesis

被引：22
作者：
Belitsky, G. A. [1 ]
Yakubovskaya, M. G. [1 ]
机构：
[1] Russian Acad Med Sci, Lab Carcinogen Screening Methods, Blokhin Canc Res Ctr, Moscow 115478, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2008年 / 73卷 / 05期
关键词：
chemical carcinogenesis; gene polymorphism; cytochrome P450; DNA repair; apoptosis; promotion; initiation;
D O I：
10.1134/S0006297908050076
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Risk assessment in chemical carcinogenesis involves ratios of several factors. Individual responses of an organism to carcinogenic agents depend on polymorphism of enzymes responsible for metabolic activation/detoxification of carcinogens, DNA repair, and apoptosis, as well as promotion and progression in malignantly transformed cells. The effects of a particular polymorphic variant are manifested only in the case of its high penetrance. An integral effect is formed by the ratio of procarcinogenic and anticarcinogenic effects. The complexity of risk assessment depends on the gene polymorphism mosaic involved, directly or indirectly, in tumorigenesis and upstream/downstream interactions of gene products.
引用
收藏
页码：543 / 554
页数：12
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