Oxysterols as non-genomic regulators of cholesterol homeostasis

被引：42

作者：

Bielska, Agata A. ^{[1
]}

Schlesinger, Paul ^{[2
]}

Covey, Douglas F. ^{[3
]}

Ory, Daniel S. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Diabet Cardiovasc Dis Ctr, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2012年 / 23卷 / 03期

基金：

美国国家卫生研究院;

关键词：

PLASMA-MEMBRANE CHOLESTEROL; ENDOPLASMIC-RETICULUM CHOLESTEROL; HMG COA REDUCTASE; PERFRINGOLYSIN-O; STEROL STRUCTURE; LXR-ALPHA; BINDING; MACROPHAGES; PROTEIN; ACYLTRANSFERASE;

D O I：

10.1016/j.tem.2011.12.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tight regulation of cellular and plasma cholesterol is crucial to proper cellular functioning because excess free cholesterol is toxic to cells and is associated with atherosclerosis and heart disease. Cellular cholesterol homeostasis is regulated by enzymatically formed oxygenated cholesterol derivatives termed oxysterols. Although the effects of oxysterols on transcriptional pathways are well described, the non-transcriptional mechanisms through which oxysterols acutely modulate cellular cholesterol levels are less well understood. We present emerging evidence suggesting that the membrane biophysical properties of oxysterols underlie their acute cholesterol-regulatory functions and discuss the relevance of these acute effects to cholesterol overload in physiological and pathophysiological states.

引用

页码：99 / 106

页数：8

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