Efficiency of intracavernosal alprostadil and oral clomiphene citrate combination treatment in penile vasculogenic erectile dysfunction patients accompanied by late-onset hypogonadism

被引:2
作者
Taskapu, Hakan Hakki [1 ]
Sonmez, Mehmet Giray [1 ]
Kilinc, Muzaffer Tansel [1 ]
Altinkaya, Nurullah [1 ]
Aydin, Arif [1 ]
Balasar, Mehmet [1 ]
机构
[1] Necmettin Erbakan Univ, Dept Urol, Meram Med Fac, Hekimoglu St, TR-42090 Konya, Turkey
关键词
alprostadil; clomiphene citrate; erectile dysfunction; hypogonadism; intracavernosal treatment; TESTOSTERONE LEVELS; MEN; EFFICACY; THERAPY; MALES; ISSAM; EAU; ISA;
D O I
10.1111/and.13759
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
In this study, the efficiency of intracavernosal alprostadil + oral clomiphene citrate (CC) treatment in late-onset hypogonadism (LOH) accompanied by penile vasculogenic erectile dysfunction (PVED) in patients irresponsive to phosphodiesterase type 5 inhibitor treatment was evaluated. A total of 31 patients with concurrent PVED and LOH were included in the study. The patients were given intracavernosal alprostadil (10-20 mu g) and oral CC (50 mg) every day for 12 weeks. Before and after treatment, a 15-question International Index of Erectile Function (IIEF-15) questionnaire, Erection Hardness Score (EHS), Sexual Encounter Profile (SEP)2 and SEP3 levels were analysed, and follicle stimulating hormone (FSH), luteinising hormone (LH), total testosterone and prostate-specific antigen (PSA) levels were measured. In all, 41.9% of patients had pure arterial deficiency, 19.3% had pure venous deficiency, and 38.7% had arterial + venous (mixed) deficiency. A significant increase was detected in total testosterone, FSH, LH and PSA values after treatment when compared to values before treatment (p < .001,p < .001,p p = .034 respectively). A significant recovery was observed in IIEF-15 subscores, EHS and SEP2-SEP3 results. In PVED patients accompanied by LOH, intracavernosal alprostadil and oral CC combination is an efficient, low cost, safely applicable and tolerable treatment.
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页数:7
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