Synthesis of Spiro-oxindole Analogs Engrafted Pyrazole Scaffold as Potential Alzheimer's Disease Therapeutics: Anti-oxidant, Enzyme Inhibitory and Molecular Docking Approaches

被引：8

作者：

Islam, Mohammad Shahidul ^{[1
,2
]}

Al-Majid, Abdullah Mohammed ^{[1
]}

Sholkamy, Essam Nageh ^{[3
]}

Yousuf, Sammer ^{[4
]}

Ayaz, Muhammad ^{[5
]}

Nawaz, Asif ^{[5
]}

Wadood, Abdul ^{[6
]}

Rehman, Ashfaq Ur ^{[7
]}

Verma, Ved Prakash ^{[2
]}

Rahman, A. F. M. Motiur ^{[8
]}

Barakat, Assem ^{[1
,9
]}

机构：

[1] King Saud Univ, Dept Chem, Coll Sci, POB 2455, Riyadh 11451, Saudi Arabia

[2] Banasthali Vidyapith, Dept Chem, Banasthali 304022, Rajasthan, India

[3] King Saud Univ, Dept Bot & Microbiol, Coll Sci, POB 2455, Riyadh 11451, Saudi Arabia

[4] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan

[5] Univ Malakand, Dept Pharm, Fac Biol Sci, Chakdara 18000, KP, Pakistan

[6] Abdul Wali Khan Univ Mardan, Dept Biochem, Mardan 23200, Pakistan

[7] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA

[8] King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, POB 2457, Riyadh 11451, Saudi Arabia

[9] Alexandria Univ, Dept Chem, Fac Sci, POB 426, Alexandria 21321, Egypt

来源：

CHEMISTRYSELECT | 2022年 / 7卷 / 36期

关键词：

Spirooxindoles; 3+2] cycloaddition reaction (32CA); Acetylcholinesterase; Alzheimer's disease (AD); BChE enzyme; Butyrylcholinesterase; DPPH; REGIOSELECTIVE SYNTHESIS; DERIVATIVES; DESIGN; ANTIFUNGAL; ANTICANCER; DISCOVERY;

D O I：

10.1002/slct.202203047

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

About 19 spirooxindole analogs 8 a-s engrafted with pyrazole scaffolds were designed and constructed via [3+2] cycloaddition reaction (32CA) approach. The synthesized spirooxindole analogs was screened for anti-cholinesterase against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) and antioxidant potentials against DPPH. The compounds 8 h and 8 i showed the strongest acetylcholine esterase (AChE) and butyrylcholinesterase (BChE) inhibition with IC50 values of 30 mu g/mL respectively. The highest anti-oxidant potential was demonstrated by compounds 8 p with IC50 values of 240 mu g/mL, respectively. Molecular docking was used to study their interaction with the active site of enzymes.

引用

页数：10

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