Graphene Oxide Nanoparticles as a Nonbleaching Optical Probe for Two-Photon Luminescence Imaging and Cell Therapy

被引：181

作者：

Li, Jing-Liang ^{[1
]}

Bao, Hong-Chun ^{[2
]}

Hou, Xue-Liang ^{[1
]}

Sun, Lu ^{[1
]}

Wang, Xun-Gai ^{[1
]}

Gu, Min ^{[2
]}

机构：

[1] Deakin Univ, Ctr Mat & Fiber Innovat, Waurn Ponds, Vic 3216, Australia

[2] Swinburne Univ Technol, Ctr Microphoton, Hawthorn, Vic 3122, Australia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 08期

关键词：

cancer; graphene oxide; imaging agents; photothermal therapy; two-photon luminescence; EXCITATION CROSS-SECTIONS; GOLD NANORODS; APOPTOSIS; DAMAGE;

D O I：

10.1002/anie.201106102

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lasting glow: Under femtosecond laser irradiation, graphene oxide nanoparticles (GONs) give strong two-photon luminescence (TPL; see picture). The presence of GONs also induces microbubbling, which causes cell death at an order of magnitude lower laser power than when cells are not labeled. The results show that GONs can be used for TPL-based imaging and photothermal cancer therapy. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1830 / 1834

页数：5

共 27 条

[1] Two-photon fluorescence excitation cross sections of biomolecular probes from 690 to 960 nm [J].

Albota, MA ;

Xu, C ;

Webb, WW .

APPLIED OPTICS, 1998, 37 (31) :7352-7356

[2] SELECTIVE MITOCHONDRIAL DAMAGE BY A RUBY LASER MICROBEAM - AN ELECTRON MICROSCOPIC STUDY [J].

AMY, RL ;

STORB, R .

SCIENCE, 1965, 150 (3697) :756-&

[3] 2-PHOTON LASER SCANNING FLUORESCENCE MICROSCOPY [J].

DENK, W ;

STRICKLER, JH ;

WEBB, WW .

SCIENCE, 1990, 248 (4951) :73-76

[4] Temperature relaxation and energy loss of hot carriers in graphene [J].

Dong, H. M. ;

Xu, W. ;

Tan, R. B. .

SOLID STATE COMMUNICATIONS, 2010, 150 (37-38) :1770-1773

[5] Photothermal Response of Human and Murine Cancer Cells to Multiwalled Carbon Nanotubes after Laser Irradiation [J].

Fisher, Jessica W. ;

Sarkar, Saugata ;

Buchanan, Cara F. ;

Szot, Christopher S. ;

Whitney, Jon ;

Hatcher, Heather C. ;

Torti, Suzy V. ;

Rylander, Christopher G. ;

Rylander, Marissa Nichole .

CANCER RESEARCH, 2010, 70 (23) :9855-9864

[6] Cancer-cell microsurgery using nonlinear optical endomicroscopy [J].

Gu, Min ;

Bao, Hong Chun ;

Li, Jing Liang .

JOURNAL OF BIOMEDICAL OPTICS, 2010, 15 (05)

[7] Deep tissue two-photon microscopy [J].

Helmchen, F ;

Denk, W .

NATURE METHODS, 2005, 2 (12) :932-940

[8] Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance [J].

Hirsch, LR ;

Stafford, RJ ;

Bankson, JA ;

Sershen, SR ;

Rivera, B ;

Price, RE ;

Hazle, JD ;

Halas, NJ ;

West, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) :13549-13554

[9] Narrow graphene nanoribbons from carbon nanotubes [J].

Jiao, Liying ;

Zhang, Li ;

Wang, Xinran ;

Diankov, Georgi ;

Dai, Hongjie .

NATURE, 2009, 458 (7240) :877-880

[10] Blood clearance and tissue distribution of PEGylated and non-PEGylated gold nanorods after intravenous administration in rats [J].

Lankveld, Danielle P. K. ;

Rayavarapu, Raja G. ;

Krystek, Petra ;

Oomen, Agnes G. ;

Verharen, Hennie W. ;

van Leeuwen, Ton G. ;

De Jong, Wim H. ;

Manohar, Srirang .

NANOMEDICINE, 2011, 6 (02) :339-349

← 1 2 3 →