A Facile Synthetic Route for the Preparation of 4-Substituted 6-Methyl-2-pyrone Derivatives via Organozinc Reagents

被引：2
作者：
Rieke, Reuben D. [2 ]
Kim, Seung-Hoi [1 ]
机构：
[1] Dankook Univ, Dept Chem, Cheonan 330714, South Korea
[2] Rieke Met Inc, Lincoln, NE 68521 USA
来源：
SYNLETT | 2011年 / 19期
关键词：
organozinc; cross-coupling reaction; 4-substituted pyrone; ALPHA-PYRONES; COUPLING REACTIONS; 3,5-DIBROMO-2-PYRONE;
D O I：
10.1055/s-0031-1289855
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel synthetic pathway for the preparation of 4-substituted 2-pyrone derivatives has been developed. It consists of two different methods; the first represents the Negishi coupling reaction utilizing easily accessible organozinc reagents. More significantly, the other is a new method utilizing a new organozinc reagent, 4-pyronylzinc bromide, which is easily prepared by highly active zinc under mild conditions.
引用
收藏
页码：2867 / 2871
页数：5
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