Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar

被引：2

作者：

Abu-Tineh, Mohammad ^{[1
]}

Kassem, Nancy ^{[2
]}

Abdulla, Mohammad Abdul-Jaber ^{[3
,4
]}

Ismai, Omar Mohammad ^{[3
,4
]}

Ghasoub, Rola ^{[2
]}

Aldapt, Mahmood B. ^{[3
,4
]}

Yassin, Mohamed A. ^{[3
,4
]}

机构：

[1] Hamad Med Corp HMC, Dept Med Educ, Doha, Qatar

[2] HMC, Dept Pharm, Natl Ctr Canc Care & Res, Doha, Qatar

[3] HMC, Natl Ctr Canc Care & Res, Dept Oncol Hematol, Doha, Qatar

[4] HMC, BMT Sect, Doha, Qatar

来源：

CASE REPORTS IN ONCOLOGY | 2020年 / 13卷 / 01期

关键词：

Essential thrombocythemia; Myeloproliferative neoplasms; Interferon; PEG-IFN alpha-2A; Pregnancy; POLYCYTHEMIA-VERA; THERAPY;

D O I：

10.1159/000506447

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myeloproliferative neoplasms are a diversified group of diseases of the hematopoietic stem cell, such as essential thrombocythemia (ET) and polycythemia vera. They are mainly caused by mutations in the following genes: JAK2, CALR, and MPL. All carry an increased risk to transform into acute leukemia or chronic myelogenous leukemia along with thrombosis and hemorrhagic complications. Treatment of such disorders during pregnancy is a challenging footstep, given the high risk of complications for both the mother and the fetus. Here, we report about two pregnant females with ET that has been treated with pegylated interferon alpha with safe and effective outcome.

引用

页码：336 / 340

页数：5

共 27 条

[1] Clinical Exome Sequencing unravels new disease-causing mutations in the myeloproliferative neoplasms: A pilot study in patients from the state of Qatar [J].