A Catalytic Intermolecular Formal Ene Reaction between Ketone-Derived Silyl Enol Ethers and Alkynes

被引：16

作者：

Holmbo, Stephen D. ^{[1
]}

Godfrey, Nicole A. ^{[1
]}

Hirner, Joshua J. ^{[1
,2
]}

Pronin, Sergey V. ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

[2] Honeywell UOP, Des Plaines, IL 60016 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 38期

基金：

美国国家科学基金会;

关键词：

ENANTIOSPECIFIC TOTAL-SYNTHESIS; STEREOSPECIFIC TOTAL-SYNTHESIS; ENDO-SELECTIVE CYCLIZATIONS; INDOLE ALKALOIDS; CARBONYL-COMPOUNDS; INTRAMOLECULAR CARBOMERCURATION; ALPHA; BETA-UNSATURATED KETONES; GENERAL-APPROACH; MILD CONDITIONS; VINYL HALIDES;

D O I：

10.1021/jacs.6b06847

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalytic formal ene reaction between ketone-derived silyl enol ethers and terminal alkynes is described. This transformation is uniquely capable of bimolecular assembly of 2-siloxy-1,4-dienes and can be used to access beta,gamma-unsaturated ketones containing quaternary carbons in the alpha-position

引用

页码：12316 / 12319

页数：4

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