Effects of prophylactic oral ibuprofen on the closure rate of patent ductus arteriosus in premature infants

被引：6
作者：
Ding, Yanjie [1 ]
Wang, Xuan [1 ]
Wu, Yanqiu [1 ]
Li, Hui [1 ]
Xu, Jiaju [1 ]
Wang, Xiaoliang [1 ]
机构：
[1] Yantai Yuhuangding Hosp, Dept Pediat, 20 Yuhuangding East Rd, Yantai 264000, Shandong Provin, Peoples R China
来源：
MEDICINE | 2018年 / 97卷 / 37期
关键词：
ibuprofen; patent ductus arteriosus; premature infants; HIGH-DOSE IBUPROFEN; PRETERM INFANTS; NATRIURETIC PEPTIDE; DOUBLE-BLIND; INDOMETHACIN; PLACEBO;
D O I：
10.1097/MD.0000000000012206
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of this study was to investigate the effects of prophylactic oral ibuprofen on the closure rate of patent ductus arteriosus (PDA). This was a retrospective study and data on infants born before 36 weeks were collected. The prophylactic group was treated with ibuprofen (10, 5, and 5mg/kg) from days 1 to 3 after birth, respectively. The conventional group was treated with the same dose of ibuprofen from days 4 to 6 once they were echocardiographically confirmed with PDA on day 3 after birth. The placebo group was treated with 5% glucose. The closure rate of PDA in the prophylactic group significantly increased on day 7 compared with the placebo group (P=.02), but showed no difference compared with the conventional group (P=.12). Serum NT-proBNP in the prophylactic and conventional groups decreased compared with the placebo group (P =.03 vs P=.07). Prophylactic oral ibuprofen can increase the closure rate of PDA in premature infants; however, it showed no significant advantages compared with conventional treatment. Serum NT-proBNP can be used to observe PDA treatment responses in premature infants.
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页数：8
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