Validation of the BrockTB stat-pak assay for detection of tuberculosis in Eurasian badgers (Meles meles) and influence of disease severity on diagnostic accuracy

被引：58

作者：

Chambers, Mark A. ^{[1
]}

Crawshaw, Tim ^{[2
]}

Waterhouse, Sue ^{[3
]}

Delahay, Richard ^{[4
]}

Hewinson, R. Glyn ^{[1
]}

Lyashchenko, Konstantin P. ^{[5
]}

机构：

[1] Vet Labs Agcy, TB Res Grp, Dept Statutory & Exot Bacterial Dis, Weybridge KT15 3NB, Surrey, England

[2] Vet Labs Agcy Starcross, Exeter EX6 8PE, Devon, England

[3] Vet Labs Agcy Langford, Bristol BS40 5DX, Avon, England

[4] Cent Sci Lab, York YO4 1LZ, N Yorkshire, England

[5] Chembio Diagnost Syst Inc, New York, NY 11763 USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2008年 / 46卷 / 04期

关键词：

D O I：

10.1128/JCM.02117-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A lateral-flow immunoassay (BrockTB Stat-Pak) for detecting tuberculosis in Eurasian badgers was 49% sensitive and 93% specific against culture for M. bovis (n = 1,464) at necropsy. However, the sensitivity was significantly higher (66 to 78%) in animals with more severe tuberculosis, indicating that the BrockTB Stat-Pak may be useful for the detection of badgers with the greatest risk of transmitting disease.

引用

页码：1498 / 1500

页数：3

共 17 条

[1] Value of existing serological tests for identifying badgers that shed Mycobacterium bovis [J].

Chambers, MA ;

Pressling, WA ;

Cheeseman, CL ;

Clifton-Hadley, RS ;

Hewinson, RG .

VETERINARY MICROBIOLOGY, 2002, 86 (03) :183-189

[2] EVALUATION OF AN ELISA FOR MYCOBACTERIUM-BOVIS INFECTION IN BADGERS (MELES-MELES) [J].

CLIFTONHADLEY, RS ;

SAYERS, AR ;

STOCK, MP .

VETERINARY RECORD, 1995, 137 (22) :555-558

[3] MYCOBACTERIUM-BOVIS IN THE EUROPEAN BADGER (MELES-MELES) - EPIDEMIOLOGIC FINDINGS IN TUBERCULOUS BADGERS FROM A NATURALLY INFECTED-POPULATION [J].

CLIFTONHADLEY, RS ;

WILESMITH, JW ;

STUART, FA .

EPIDEMIOLOGY AND INFECTION, 1993, 111 (01) :9-19

[4] The role of wild animal populations in the epidemiology of tuberculosis in domestic animals: How to assess the risk [J].

Corner, LAL .

VETERINARY MICROBIOLOGY, 2006, 112 (2-4) :303-312

[5]

DAILEY D, IN PRESS TUBERCULOSI

[6] The spatio-temporal distribution of Mycobacterium bovis (bovine tuberculosis) infection in a high-density badger population [J].

Delahay, RJ ;

Langton, S ;

Smith, GC ;

Clifton-Hadley, RS ;

Cheeseman, CL .

JOURNAL OF ANIMAL ECOLOGY, 2000, 69 (03) :428-441

[7]

*DEP ENV FOOD RUR, 2007, AN HLTH 2006 REP CHI

[8] Impacts of widespread badger culling on cattle tuberculosis: concluding analyses from a large-scale field trial [J].

Donnelly, Christl A. ;

Wei, Gao ;

Johnston, W. Thomas ;

Cox, D. R. ;

Woodroffe, Rosie ;

Bourne, F. John ;

Cheeseman, C. L. ;

Clifton-Hadley, Richard S. ;

Gettinby, George ;

Gilks, Peter ;

Jenkins, Helen E. ;

Le Fevre, Andrea M. ;

McInerney, John P. ;

Morrison, W. Ivan .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2007, 11 (04) :300-308

[9] Molecular epidemiology of bovine tuberculosis -: I.: Mycobacterium bovis genotyping [J].

Durr, PA ;

Hewinson, RG ;

Clifton-Hadley, RS .

REVUE SCIENTIFIQUE ET TECHNIQUE DE L OFFICE INTERNATIONAL DES EPIZOOTIES, 2000, 19 (03) :675-688

[10] Role of infected, non-diseased badgers in the pathogenesis of tuberculosis in the badger [J].

Gallagher, J ;

Monies, R ;

Gavier-Widen, M ;

Rule, B .

VETERINARY RECORD, 1998, 142 (26) :710-714

← 1 2 →